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Maml1 mastermind-like transcriptional coactivator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303101, updated on 13-Apr-2024

Summary

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Official Symbol
Maml1provided by RGD
Official Full Name
mastermind-like transcriptional coactivator 1provided by RGD
Primary source
RGD:1308631
See related
Ensembl:ENSRNOG00000003268 AllianceGenome:RGD:1308631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable peptide antigen binding activity; protein kinase binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including atrioventricular node cell development; positive regulation of myotube differentiation; and positive regulation of transcription of Notch receptor target. Predicted to act upstream of or within Notch signaling pathway; myoblast differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of MAML1-RBP-Jkappa- ICN1 complex. Predicted to be active in nucleoplasm. Orthologous to human MAML1 (mastermind like transcriptional coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 44.8), Spleen (RPKM 39.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Maml1 in Genome Data Viewer
Location:
10q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (35089715..35124100, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34588639..34623024, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35765196..35801375, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sequestosome 1 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene uncharacterized LOC134480781 Neighboring gene leukotriene C4 synthase Neighboring gene uncharacterized LOC120095092 Neighboring gene calnexin Neighboring gene uncharacterized LOC134480780

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, et al. Neuroscience, 2015 Aug 20. PMID 26067594
  2. Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. Rentschler S, et al. J Clin Invest, 2011 Feb. PMID 21266778, Free PMC Article
  3. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Wu L, et al. Nat Genet, 2000 Dec. PMID 11101851
  4. Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene. Wu L, et al. Gene, 2004 Mar 17. PMID 15019995
  5. The notch regulator MAML1 interacts with p53 and functions as a coactivator. Zhao Y, et al. J Biol Chem, 2007 Apr 20. PMID 17317671

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in atrioventricular node cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in myoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription of Notch receptor target IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription of Notch receptor target ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MAML1-RBP-Jkappa- ICN1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mastermind-like protein 1
Names
mastermind like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401556.1 → NP_001388485.1  mastermind-like protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D4A930
    Related
    ENSRNOP00000004361.6, ENSRNOT00000004361.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    35089715..35124100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106997.1: Suppressed sequence

    Description
    NM_001106997.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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