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Septin8 septin 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303135, updated on 6-Jun-2024

Summary

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Official Symbol
Septin8provided by RGD
Official Full Name
septin 8provided by RGD
Primary source
RGD:1308449
See related
Ensembl:ENSRNOG00000007462 AllianceGenome:RGD:1308449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables SNARE binding activity. Involved in regulation of SNARE complex assembly. Located in myelin sheath. Is active in presynapse. Orthologous to human SEPTIN8 (septin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 203.9), Heart (RPKM 95.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Septin8 in Genome Data Viewer
Location:
10q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (38185454..38214502)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (37684649..37713704)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (38877422..38906480)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene shroom family member 1 Neighboring gene sosondowah ankyrin repeat domain family member A Neighboring gene kinesin family member 3a Neighboring gene interleukin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Localization of septin 8 in murine retina, and spatiotemporal expression of septin 8 in a murine model of photoreceptor cell degeneration. Hara A, et al. Neurosci Lett, 2007 Aug 23. PMID 17709200
  2. Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin. Ito H, et al. J Neurochem, 2009 Feb. PMID 19196426
  3. SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. Kurkinen KM, et al. J Cell Sci, 2016 Jun 1. PMID 27084579
  4. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, et al. J Neurosci Res, 2008 Mar. PMID 17960831
  5. Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission. Tsang CW, et al. Mol Cell Biol, 2008 Dec. PMID 18809578, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that Sept8 may participate in the process of the SNARE complex formation and subsequent neurotransmitter release.
    Title: Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin.
  2. Septin 8 is present in specific location within retina. Disappearance of septin 8 in nuclei of photoreceptor cells is concomitant with nuclear DNA fragmentation.
    Title: Localization of septin 8 in murine retina, and spatiotemporal expression of septin 8 in a murine model of photoreceptor cell degeneration.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of SNARE complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myelin sheath IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
septin-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107002.2 → NP_001100472.1  septin-8 isoform 2

    See identical proteins and their annotated locations for NP_001100472.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    B0BNF1
    UniProtKB/TrEMBL
    A6HED2, G3V9Z6
    Related
    ENSRNOP00000063893.1, ENSRNOT00000065229.3
    Conserved Domains (1) summary
    cd01850
    Location:41 → 309
    CDC_Septin; CDC/Septin GTPase family

  2. NM_001414347.1 → NP_001401276.1  septin-8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2JVY6, A0A0G2K7G7
    Related
    ENSRNOP00000074199.1, ENSRNOT00000083162.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    38185454..38214502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268976.1 → XP_063125046.1  septin-8 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JVY6

  2. XM_006246268.3 → XP_006246330.1  septin-8 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JVY6
    Conserved Domains (1) summary
    cd01850
    Location:41 → 307
    CDC_Septin; CDC/Septin GTPase family

  3. XM_017597256.3 → XP_017452745.2  septin-8 isoform X6

    UniProtKB/Swiss-Prot
    B0BNF1

  4. XM_017597258.2 → XP_017452747.1  septin-8 isoform X4

    UniProtKB/Swiss-Prot
    B0BNF1

  5. XM_063268977.1 → XP_063125047.1  septin-8 isoform X7

    UniProtKB/Swiss-Prot
    B0BNF1

  6. XM_063268978.1 → XP_063125048.1  septin-8 isoform X8

    UniProtKB/Swiss-Prot
    B0BNF1

  7. XM_017597255.3 → XP_017452744.2  septin-8 isoform X5

    UniProtKB/Swiss-Prot
    B0BNF1

  8. XM_063268979.1 → XP_063125049.1  septin-8 isoform X9

    UniProtKB/TrEMBL
    A0A0G2JVY6

  9. XM_017597254.3 → XP_017452743.1  septin-8 isoform X10

    UniProtKB/TrEMBL
    A0A0G2JVY6

  10. XM_063268980.1 → XP_063125050.1  septin-8 isoform X11

    UniProtKB/TrEMBL
    A0A0G2JVY6

  11. XM_063268975.1 → XP_063125045.1  septin-8 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JVY6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0BNF1.1 GenPept UniProtKB/Swiss-Prot:B0BNF1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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