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Top3a DNA topoisomerase III alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 303194, updated on 3-Apr-2024

Summary

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Official Symbol
Top3aprovided by RGD
Official Full Name
DNA topoisomerase III alphaprovided by RGD
Primary source
RGD:1309320
See related
Ensembl:ENSRNOG00000005099 AllianceGenome:RGD:1309320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity and single-stranded DNA binding activity. Predicted to be involved in DNA topological change; chromosome separation; and mitochondrial DNA metabolic process. Predicted to be located in PML body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Orthologous to human TOP3A (DNA topoisomerase III alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 110.0), Testes (RPKM 67.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q22
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45915625..45956856, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45419219..45457356, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46980646..47018728, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA15 Neighboring gene FLII, actin remodeling protein Neighboring gene mitochondrial elongation factor 2 Neighboring gene SMCR8-C9orf72 complex subunit Neighboring gene serine hydroxymethyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in TOP3A Cause a Bloom Syndrome-like Disorder. Martin CA, et al. Am J Hum Genet, 2018 Aug 2. PMID 30057030, Free PMC Article
  2. Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA. Nicholls TJ, et al. Mol Cell, 2018 Jan 4. PMID 29290614, Free PMC Article
  3. Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1. Yang J, et al. J Biol Chem, 2010 Jul 9. PMID 20445207, Free PMC Article
  4. Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. Johnson FB, et al. Cancer Res, 2000 Mar 1. PMID 10728666
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA topological change ISO
Inferred from Sequence Orthology
more info
  
involved_in chromosome separation ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial DNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in resolution of DNA recombination intermediates ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
part_of RecQ family helicase-topoisomerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RecQ family helicase-topoisomerase III complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA topoisomerase 3-alpha
Names
topoisomerase (DNA) III alpha
NP_001414385.1
XP_038943192.1
XP_038943193.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427456.2 → NP_001414385.1  DNA topoisomerase 3-alpha

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    45915625..45956856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087265.2 → XP_038943193.1  DNA topoisomerase 3-alpha isoform X2

    Conserved Domains (3) summary
    cd03362
    Location:35 → 193
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    cd00186
    Location:202 → 617
    TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
    pfam01396
    Location:655 → 673
    zf-C4_Topoisom; Topoisomerase DNA binding C4 zinc finger

  2. XM_039087264.2 → XP_038943192.1  DNA topoisomerase 3-alpha isoform X1

    UniProtKB/TrEMBL
    D4A6J4
    Conserved Domains (4) summary
    cd03362
    Location:8 → 138
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    cd00186
    Location:147 → 562
    TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
    pfam01396
    Location:600 → 639
    zf-C4_Topoisom; Topoisomerase DNA binding C4 zinc finger
    pfam06839
    Location:843 → 886
    zf-GRF; GRF zinc finger
Nucleotide Protein Strain
Heading Accession and Version

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