U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ctc1 CST telomere replication complex component 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303238, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Ctc1provided by RGD
Official Full Name
CST telomere replication complex component 1provided by RGD
Primary source
RGD:1563106
See related
Ensembl:ENSRNOG00000005357 AllianceGenome:RGD:1563106
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563106
Summary
Predicted to enable G-rich strand telomeric DNA binding activity. Predicted to be involved in negative regulation of telomere maintenance via telomerase; positive regulation of DNA replication; and telomere maintenance via telomere lengthening. Predicted to act upstream of or within several processes, including hematopoietic or lymphoid organ development; positive regulation of fibroblast proliferation; and replicative senescence. Predicted to be located in chromosome, telomeric region; cytosol; and nucleoplasm. Predicted to be part of CST complex. Orthologous to human CTC1 (CST telomere replication complex component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 110.3), Kidney (RPKM 106.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ctc1 in Genome Data Viewer
Location:
10q24
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54212537..54234146)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53714614..53735298)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55596172..55616873)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phosphoribosylformylglycinamidine synthase Neighboring gene small nucleolar RNA SNORA7 Neighboring gene transfer RNA isoleucine (anticodon AAU) 5 Neighboring gene transfer RNA serine (anticodon AGA) 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes. Surovtseva YV, et al. Mol Cell, 2009 Oct 23. PMID 19854131, Free PMC Article
  2. CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. Gu P, et al. EMBO J, 2012 May 16. PMID 22531781, Free PMC Article
  3. A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. Casteel DE, et al. J Biol Chem, 2009 Feb 27. PMID 19119139, Free PMC Article
  4. The human CST complex is a terminator of telomerase activity. Chen LY, et al. Nature, 2012 Aug 23. PMID 22763445
  5. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Miyake Y, et al. Mol Cell, 2009 Oct 23. PMID 19854130

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-rich strand telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within bone marrow development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within replicative senescence ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spleen development ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomere lengthening IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within thymus development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CST complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CST complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
CST complex subunit CTC1
Names
CTS telomere maintenance complex component 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107010.1 → NP_001100480.1  CST complex subunit CTC1

    See identical proteins and their annotated locations for NP_001100480.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A8I6AE77, A6HFM6
    Related
    ENSRNOP00000091731.1, ENSRNOT00000117121.1
    Conserved Domains (1) summary
    pfam15489
    Location:61 → 1195
    CTC1; CST, telomere maintenance, complex subunit CTC1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    54212537..54234146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246699.5 → XP_006246761.1  CST complex subunit CTC1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AE77, D4A261
    Related
    ENSRNOP00000007447.7
    Conserved Domains (1) summary
    pfam15489
    Location:61 → 1196
    CTC1; CST, telomere maintenance, complex subunit CTC1

  2. XM_006246700.3 → XP_006246762.1  CST complex subunit CTC1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AE77
    Conserved Domains (1) summary
    pfam15489
    Location:1 → 960
    CTC1; CST, telomere maintenance, complex subunit CTC1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous