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Dnah2 dynein, axonemal, heavy chain 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303242, updated on 13-Apr-2024

Summary

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Symbol
Dnah2provided by RGD
Full Name
dynein, axonemal, heavy chain 2provided by RGD
Primary source
RGD:1565087
See related
Ensembl:ENSRNOG00000052688 AllianceGenome:RGD:1565087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DLP2; axo f; Dnahc2
Summary
Predicted to enable ATP binding activity. Predicted to be involved in cilium-dependent cell motility. Predicted to be located in axoneme and sperm flagellum. Predicted to be part of axonemal dynein complex. Human ortholog(s) of this gene implicated in spermatogenic failure 45. Orthologous to human DNAH2 (dynein axonemal heavy chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 78.6), Lung (RPKM 22.7) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q24
Exon count:
89
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54641450..54766502, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54142648..54268901, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56029022..56154602, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 38, NatC auxiliary subunit Neighboring gene transmembrane protein 88 Neighboring gene lysine demethylase 6B Neighboring gene uncharacterized LOC102557224 Neighboring gene ephrin B3 Neighboring gene WD repeat containing, antisense to TP53

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of seven rat axonemal dynein heavy chain genes: expression during ciliated cell differentiation. Andrews KL, et al. Mol Biol Cell, 1996 Jan. PMID 8741840, Free PMC Article
  2. Rat hd mutation reveals an essential role of centrobin in spermatid head shaping and assembly of the head-tail coupling apparatus. Liska F, et al. Biol Reprod, 2009 Dec. PMID 19710508, Free PMC Article
  3. Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. Takeda S, et al. J Cell Biol, 1999 May 17. PMID 10330409, Free PMC Article
  4. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka Y, et al. J Cell Sci, 1995 May. PMID 7657712
  5. Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia. Whitfield M, et al. Am J Hum Genet, 2019 Jul 3. PMID 31178125, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium-dependent cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in inner dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of axonemal dynein complex ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
part_of inner dynein arm ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynein axonemal heavy chain 2
Names
axonemal dynein heavy chain
dynein heavy chain 2, axonemal
dynein heavy chain 2, axonemal-like
dynein-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100676.1 → NP_001094146.1  dynein axonemal heavy chain 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2JYL5
    Related
    ENSRNOP00000070702.1, ENSRNOT00000090809.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    54641450..54766502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767900.4 → XP_008766122.1  dynein axonemal heavy chain 2 isoform X1

    See identical proteins and their annotated locations for XP_008766122.1

    UniProtKB/TrEMBL
    Q2KML4
    Conserved Domains (6) summary
    pfam03028
    Location:3455 → 4146
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:3 → 456
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:954 → 1359
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:2737 → 3069
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:3097 → 3313
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:1496 → 1726
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_039087610.2 → XP_038943538.1  dynein axonemal heavy chain 2 isoform X2

    UniProtKB/TrEMBL
    Q2KML4
    Conserved Domains (4) summary
    COG5245
    Location:930 → 3751
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:2 → 360
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam12774
    Location:1408 → 1734
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:3766 → 4066
    Dynein_C; Dynein heavy chain C-terminal domain

  3. XM_039087611.2 → XP_038943539.1  dynein axonemal heavy chain 2 isoform X3

    Conserved Domains (3) summary
    COG5245
    Location:92 → 2492
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12774
    Location:149 → 475
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:2507 → 2807
    Dynein_C; Dynein heavy chain C-terminal domain

  4. XM_039087612.2 → XP_038943540.1  dynein axonemal heavy chain 2 isoform X4

    Conserved Domains (5) summary
    pfam08385
    Location:241 → 798
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1301 → 1709
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1846 → 2172
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam17852
    Location:2334 → 2430
    Dynein_AAA_lid; Dynein heavy chain AAA lid domain
    cl38936
    Location:2162 → 2303
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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