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Ccnq cyclin Q [ Rattus norvegicus (Norway rat) ]

Gene ID: 303321, updated on 5-Mar-2024

Summary

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Official Symbol
Ccnqprovided by RGD
Official Full Name
cyclin Qprovided by RGD
Primary source
RGD:1305651
See related
Ensembl:ENSRNOG00000022582 AllianceGenome:RGD:1305651
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam58a; Fam58b; RGD1305651
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity and protein kinase activator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndactyly-telecanthus-anogenital and renal malformations syndrome. Orthologous to several human genes including CCNQ (cyclin Q). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See Ccnq in Genome Data Viewer
Location:
10q25
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (64144560..64145723, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63646532..63647695, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (66019519..66020682, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene nemo like kinase Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like Neighboring gene LYR motif containing 9 like 1 Neighboring gene LYR motif containing 9 Neighboring gene uncharacterized LOC120095150

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Guen VJ, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218572, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-Q
Names
CDK10-activating cyclin
cyclin-M
cyclin-related protein FAM58A
family with sequence similarity 58, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025412.1 → NP_001020583.1  cyclin-Q

    See identical proteins and their annotated locations for NP_001020583.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097941
    UniProtKB/Swiss-Prot
    Q4QQW5, Q5RJY7
    UniProtKB/TrEMBL
    A6HH70
    Related
    ENSRNOP00000011019.2, ENSRNOT00000011019.4
    Conserved Domains (2) summary
    cd20534
    Location:29 → 137
    CYCLIN_CCNM_CCNQ_rpt1; first cyclin box found in cyclin-M (CCNM) family
    cd20535
    Location:142 → 245
    CYCLIN_CCNM_CCNQ_rpt2; second cyclin box found in cyclin-M (CCNM) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    64144560..64145723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QQW5.1 GenPept UniProtKB/Swiss-Prot:Q4QQW5

Gene LinkOut

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