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Wsb1 WD repeat and SOCS box-containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303336, updated on 3-Apr-2024

Summary

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Official Symbol
Wsb1provided by RGD
Official Full Name
WD repeat and SOCS box-containing 1provided by RGD
Primary source
RGD:1307835
See related
Ensembl:ENSRNOG00000012929 AllianceGenome:RGD:1307835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein K27-linked ubiquitination. Predicted to act upstream of or within protein aggregate center assembly. Predicted to be located in cytoplasm. Orthologous to human WSB1 (WD repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 343.8), Brain (RPKM 249.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wsb1 in Genome Data Viewer
Location:
10q25
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (64700752..64717038, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (64202761..64219039, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (66586905..66602984, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase 2, pseudogene 1 Neighboring gene galectin 9 Neighboring gene kinase suppressor of ras 1 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion like 2 Neighboring gene uncharacterized LOC120095152 Neighboring gene uncharacterized LOC102552371

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain. Fekete C, et al. Endocrinology, 2007 Oct. PMID 17628004
  2. Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary. Zhang X, et al. Biol Trace Elem Res, 2016 Dec. PMID 27156111
  3. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WSB1, as an E3 ligase, restrains myocardial ischemia-reperfusion injury by activating beta-catenin signaling via promoting GSK3beta ubiquitination.
    Title: WSB1, as an E3 ligase, restrains myocardial ischemia-reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination.
  2. High iodine intake had no discernible effects on USP20. Temporary increases in USP33 and USP19 mRNA levels were observed. The enzymes related to D2 ubiquitination change with prolonged high iodine intake. Increased D2 ubiquitination suppresses the activity of D2, causing a decrease in negative feedback of the hypothalamic-pituitary-thyroid axis.
    Title: Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary.
  3. Correlation between relative mRNA levels of WSB-1 and USP-33 in numerous tissues that do not express type 2 deiodinase(D2) suggests that these ubiquitin-related enzymes share additional substrates besides D2.
    Title: Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC112712

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K27-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein aggregate center assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat and SOCS box-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025664.1 → NP_001020835.2  WD repeat and SOCS box-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001020835.2

    Status: VALIDATED

    Source sequence(s)
    BC098720
    UniProtKB/TrEMBL
    Q4KM78
    Conserved Domains (3) summary
    cd03746
    Location:140 → 179
    SOCS_WSB1_SWIP1; SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 ...
    sd00039
    Location:17 → 57
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:1 → 146
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001042561.1 → NP_001036026.1  WD repeat and SOCS box-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001036026.1

    Status: VALIDATED

    Source sequence(s)
    BC098720, CK473503, DY312839
    UniProtKB/TrEMBL
    A6HH82, B3DM89, F7FCT1
    Related
    ENSRNOP00000017949.4, ENSRNOT00000017949.6
    Conserved Domains (4) summary
    COG2319
    Location:38 → 382
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:135 → 388
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd03746
    Location:382 → 421
    SOCS_WSB1_SWIP1; SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 ...
    sd00039
    Location:174 → 212
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    64700752..64717038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269072.1 → XP_063125142.1  WD repeat and SOCS box-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    Q4KM78

  2. XM_017597304.2 → XP_017452793.1  WD repeat and SOCS box-containing protein 1 isoform X2

    Conserved Domains (4) summary
    COG2319
    Location:15 → 167
    WD40; WD40 repeat [General function prediction only]
    cd03746
    Location:159 → 198
    SOCS_WSB1_SWIP1; SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 ...
    sd00039
    Location:36 → 76
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:15 → 165
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_063269071.1 → XP_063125141.1  WD repeat and SOCS box-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A6HH83
Nucleotide Protein Strain
Heading Accession and Version

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