Atad5 ATPase family, AAA domain containing 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atad5provided by RGD
Official Full Name: ATPase family, AAA domain containing 5provided by RGD
Primary source: RGD:1561464
See related: Ensembl:ENSRNOG00000021903 AllianceGenome:RGD:1561464
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561464
Summary: Predicted to enable DNA binding activity and DNA clamp unloader activity. Predicted to be involved in several processes, including DNA clamp unloading; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and positive regulation of cell cycle G2/M phase transition. Predicted to act upstream of or within several processes, including intracellular signal transduction; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of B cell activation. Predicted to be part of Elg1 RFC-like complex. Predicted to be active in nucleus. Orthologous to human ATAD5 (ATPase family AAA domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 103.6), Spleen (RPKM 72.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (65568569..65616379)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (65070682..65118489)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (67427042..67475825)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142534 (e-PCR)
- UniSTS:231781

BE107606 (e-PCR)
- UniSTS:246955

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA clamp unloader activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA clamp unloader activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA clamp unloading	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of isotype switching	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in nuclear DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle G2/M phase transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitotic cell cycle phase transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction in response to DNA damage	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Elg1 RFC-like complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATPase family AAA domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

65568569..65616379

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_220750.11 → XP_220750.6 ATPase family AAA domain-containing protein 5 isoform X1

See identical proteins and their annotated locations for XP_220750.6

UniProtKB/TrEMBL

A6HHA2, D4A058

Related

ENSRNOP00000028975.5

Conserved Domains (1) summary

cl21455
Location:1121 → 1166

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039087647.2 → XP_038943575.1 ATPase family AAA domain-containing protein 5 isoform X2

UniProtKB/TrEMBL

A6HHA2

Conserved Domains (1) summary

PRK04195
Location:1045 → 1348

PRK04195; replication factor C large subunit; Provisional
XM_006246963.5 → XP_006247025.1 ATPase family AAA domain-containing protein 5 isoform X3

See identical proteins and their annotated locations for XP_006247025.1

UniProtKB/TrEMBL

A6HHA2

Conserved Domains (1) summary

cl21455
Location:1058 → 1103

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases