Abi3 ABI family, member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abi3provided by RGD
Official Full Name: ABI family, member 3provided by RGD
Primary source: RGD:1311794
See related: Ensembl:ENSRNOG00000005575 AllianceGenome:RGD:1311794
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable SH3 domain binding activity and identical protein binding activity. Predicted to be involved in several processes, including defense response to tumor cell; negative regulation of lamellipodium assembly; and positive regulation of cellular senescence. Predicted to be located in cytoplasm. Predicted to be part of SCAR complex. Predicted to be active in lamellipodium. Orthologous to human ABI3 (ABI family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 209.2), Lung (RPKM 82.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (81266571..81277561, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (80769819..80780816, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (83644086..83655182, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AI987680 (e-PCR)
- UniSTS:165796

RH133502 (e-PCR)
- UniSTS:216785

AW434650 (e-PCR)
- UniSTS:248790

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defense response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	IEP Inferred from Expression Pattern more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	ISO Inferred from Sequence Orthology more info
is_active_in actin-based cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ABI gene family member 3

Names: ABI gene family, member 3; NESH protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013118.1 → NP_001013136.1 ABI gene family member 3

See identical proteins and their annotated locations for NP_001013136.1

Status: PROVISIONAL

Source sequence(s)

BC079102

UniProtKB/TrEMBL

A0A8I5ZSD9, F7FKP3, Q6AYC6

Related

ENSRNOP00000007897.2, ENSRNOT00000007897.4

Conserved Domains (2) summary

cd11826
Location:313 → 364

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:96 → 167

Abi_HHR; Abl-interactor HHR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

81266571..81277561 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086071.2 → XP_038941999.1 ABI gene family member 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZSD9

Conserved Domains (2) summary

cd11826
Location:312 → 363

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:96 → 159

Abi_HHR; Abl-interactor HHR
XM_063269113.1 → XP_063125183.1 ABI gene family member 3 isoform X2