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Snx11 sorting nexin 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303493, updated on 6-Jun-2024

Summary

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Official Symbol
Snx11provided by RGD
Official Full Name
sorting nexin 11provided by RGD
Primary source
RGD:1307319
See related
Ensembl:ENSRNOG00000008642 AllianceGenome:RGD:1307319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in vesicle organization. Predicted to be located in endosome. Orthologous to human SNX11 (sorting nexin 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 79.6), Kidney (RPKM 55.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Snx11 in Genome Data Viewer
Location:
10q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82238475..82249264, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81742020..81752778, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84628420..84639125, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene src kinase associated phosphoprotein 1 Neighboring gene uncharacterized LOC120095286 Neighboring gene uncharacterized LOC102551165 Neighboring gene uncharacterized LOC134480860 Neighboring gene chromobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. Xu J, et al. J Biol Chem, 2013 Jun 7. PMID 23615901, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sorting nexin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012012.2 → NP_001012012.2  sorting nexin-11

    See identical proteins and their annotated locations for NP_001012012.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC086543, CO558022, DN932564
    UniProtKB/TrEMBL
    A0A8I5Y9D6, A6HIG1, D4A3W4
    Related
    ENSRNOP00000011474.4, ENSRNOT00000011474.7
    Conserved Domains (1) summary
    cd06898
    Location:18 → 129
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  2. NM_001199169.1 → NP_001186098.1  sorting nexin-11

    See identical proteins and their annotated locations for NP_001186098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC086543, CO558022, DN932564
    UniProtKB/TrEMBL
    A0A8I5Y9D6, A6HIG1, D4A3W4
    Related
    ENSRNOP00000077201.1, ENSRNOT00000096544.1
    Conserved Domains (1) summary
    cd06898
    Location:18 → 129
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    82238475..82249264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247196.4 → XP_006247258.1  sorting nexin-11 isoform X1

    See identical proteins and their annotated locations for XP_006247258.1

    UniProtKB/TrEMBL
    A0A8I5Y9D6, A6HIG1, D4A3W4
    Conserved Domains (1) summary
    cd06898
    Location:18 → 129
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  2. XM_006247198.4 → XP_006247260.1  sorting nexin-11 isoform X1

    See identical proteins and their annotated locations for XP_006247260.1

    UniProtKB/TrEMBL
    A0A8I5Y9D6, A6HIG1, D4A3W4
    Conserved Domains (1) summary
    cd06898
    Location:18 → 129
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  3. XM_063269114.1 → XP_063125184.1  sorting nexin-11 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y9D6, A6HIG1, D4A3W4

  4. XM_039086077.2 → XP_038942005.1  sorting nexin-11 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JXH9, Q5RJQ6
    Conserved Domains (1) summary
    cl02563
    Location:18 → 76
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
Nucleotide Protein Strain
Heading Accession and Version

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