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Odad4 outer dynein arm docking complex subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303534, updated on 5-Mar-2024

Summary

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Official Symbol
Odad4provided by RGD
Official Full Name
outer dynein arm docking complex subunit 4provided by RGD
Primary source
RGD:1311859
See related
Ensembl:ENSRNOG00000017473 AllianceGenome:RGD:1311859
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ttc25; RGD1311859
Summary
Predicted to be involved in mucociliary clearance and protein localization to motile cilium. Predicted to act upstream of or within animal organ development; epithelial cilium movement involved in extracellular fluid movement; and outer dynein arm assembly. Predicted to be located in 9+0 motile cilium; 9+2 motile cilium; and axoneme. Predicted to be part of outer dynein arm docking complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 35. Orthologous to human ODAD4 (outer dynein arm docking complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 76.0), Adrenal (RPKM 27.9) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (85980440..86008943)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85480089..85508603)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88459490..88488237)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP citrate lyase Neighboring gene transfer RNA serine (anticodon AGA) 28 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene NFKB inhibitor interacting Ras-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebrospinal fluid circulation ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cilium movement involved in determination of left/right asymmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of heart development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of lung development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
  
involved_in mucociliary clearance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to motile cilium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in 9+0 motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in 9+2 motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of outer dynein arm docking complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
outer dynein arm-docking complex subunit 4
Names
tetratricopeptide repeat domain 25
tetratricopeptide repeat protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107049.1 → NP_001100519.1  outer dynein arm-docking complex subunit 4

    See identical proteins and their annotated locations for NP_001100519.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A0G2KAE9, A6HJ41, B1WCA2
    Related
    ENSRNOP00000075373.1, ENSRNOT00000080231.2
    Conserved Domains (3) summary
    sd00006
    Location:18 → 43
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:18 → 80
    TPR_11; TPR repeat
    pfam13424
    Location:400 → 470
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    85980440..86008943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086089.2 → XP_038942017.1  outer dynein arm-docking complex subunit 4 isoform X2

    UniProtKB/TrEMBL
    G3V9Y3
    Related
    ENSRNOP00000063052.2
    Conserved Domains (3) summary
    TIGR00990
    Location:22 → 103
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:18 → 43
    TPR; TPR repeat [structural motif]
    pfam17874
    Location:325 → 472
    TPR_MalT; MalT-like TPR region

  2. XM_039086088.2 → XP_038942016.1  outer dynein arm-docking complex subunit 4 isoform X1

    Conserved Domains (3) summary
    sd00006
    Location:86 → 124
    TPR; TPR repeat [structural motif]
    cd06503
    Location:251 → 329
    ATP-synt_Fo_b; F-type ATP synthase, membrane subunit b
    pfam17874
    Location:98 → 245
    TPR_MalT; MalT-like TPR region
Nucleotide Protein Strain
Heading Accession and Version

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