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Dhx58 DEXH-box helicase 58 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303538, updated on 11-Apr-2024

Summary

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Official Symbol
Dhx58provided by RGD
Official Full Name
DEXH-box helicase 58provided by RGD
Primary source
RGD:1310093
See related
Ensembl:ENSRNOG00000018247 AllianceGenome:RGD:1310093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lgp2; RGD1310093
Summary
Predicted to enable double-stranded RNA binding activity; single-stranded RNA binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of innate immune response; regulation of type I interferon production; and regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway. Predicted to act upstream of or within response to bacterium. Predicted to be active in cytoplasm. Orthologous to human DHX58 (DExH-box helicase 58). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 62.6), Lung (RPKM 48.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86120677..86132095, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85620352..85631776, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88599722..88611562, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA44 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 10 C17orf113 homolog pseudogene Neighboring gene uncharacterized LOC120095293 Neighboring gene lysine acetyltransferase 2A Neighboring gene heat shock protein family B (small) member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA. Li X, et al. J Biol Chem, 2009 May 15. PMID 19278996, Free PMC Article
  2. Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response. Murali A, et al. J Biol Chem, 2008 Jun 6. PMID 18411269, Free PMC Article
  3. Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. Venkataraman T, et al. J Immunol, 2007 May 15. PMID 17475874
  4. Ambivalent role of the innate immune response in rabies virus pathogenesis. Chopy D, et al. J Virol, 2011 Jul. PMID 21525357, Free PMC Article
  5. LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Satoh T, et al. Proc Natl Acad Sci U S A, 2010 Jan 26. PMID 20080593, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional analysis of the human LGP2 ortholog.
    Title: RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic pattern recognition receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MDA-5 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of RIG-I signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MDA-5 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DHX58
Names
DEXH (Asp-Glu-X-His) box polypeptide 58
RNA helicase LGP2
probable ATP-dependent RNA helicase DHX58
NP_001092258.1
XP_006247376.1
XP_006247377.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098788.1 → NP_001092258.1  ATP-dependent RNA helicase DHX58

    See identical proteins and their annotated locations for NP_001092258.1

    Status: VALIDATED

    Source sequence(s)
    BP488074, CB544595, CB546277, CR460878, JAXUCZ010000010
    UniProtKB/TrEMBL
    D3ZD46
    Related
    ENSRNOP00000024718.4, ENSRNOT00000024718.6
    Conserved Domains (4) summary
    cd15806
    Location:552 → 664
    LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
    cd12090
    Location:227 → 342
    MDA5_ID; Insert domain of MDA5
    cd18802
    Location:349 → 483
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cl28899
    Location:1 → 200
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86120677..86132095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247314.5 → XP_006247376.1  ATP-dependent RNA helicase DHX58 isoform X1

    See identical proteins and their annotated locations for XP_006247376.1

    UniProtKB/TrEMBL
    D3ZD46
    Conserved Domains (4) summary
    cd15806
    Location:552 → 664
    LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
    cd12090
    Location:227 → 342
    MDA5_ID; Insert domain of MDA5
    cd18802
    Location:349 → 483
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cl28899
    Location:1 → 200
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  2. XM_006247315.5 → XP_006247377.1  ATP-dependent RNA helicase DHX58 isoform X1

    See identical proteins and their annotated locations for XP_006247377.1

    UniProtKB/TrEMBL
    D3ZD46
    Conserved Domains (4) summary
    cd15806
    Location:552 → 664
    LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
    cd12090
    Location:227 → 342
    MDA5_ID; Insert domain of MDA5
    cd18802
    Location:349 → 483
    SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
    cl28899
    Location:1 → 200
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
Nucleotide Protein Strain
Heading Accession and Version

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