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Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 303547, updated on 11-Apr-2024

Summary

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Official Symbol
Ezh1provided by RGD
Official Full Name
enhancer of zeste 1 polycomb repressive complex 2 subunitprovided by RGD
Primary source
RGD:1305028
See related
Ensembl:ENSRNOG00000020336 AllianceGenome:RGD:1305028
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables chromatin binding activity. Involved in hippocampus development and positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 177.3), Lung (RPKM 163.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q31
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86626307..86662257, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86126023..86162001, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89104026..89139978, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H3 Neighboring gene contactin associated protein 1 Neighboring gene C-C motif chemokine receptor 10 Neighboring gene uncharacterized LOC134480876 Neighboring gene uncharacterized LOC120095184 Neighboring gene receptor activity modifying protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration. Bae WK, et al. FASEB J, 2015 May. PMID 25477280, Free PMC Article
  2. Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons. Henriquez B, et al. Mol Cell Neurosci, 2013 Nov. PMID 23932971
  3. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Margueron R, et al. Mol Cell, 2008 Nov 21. PMID 19026781, Free PMC Article
  4. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, et al. Trends Biochem Sci, 2013 Dec. PMID 24148750, Free PMC Article
  5. Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. van Lohuizen M, et al. Mol Cell Biol, 1998 Jun. PMID 9584197, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. knock-down of Ezh1 reduces PSD-95 transcription in developing hippocampal neurons
    Title: Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K27 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K27 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K27 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to histone binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular condensate scaffold activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleosome binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in facultative heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hepatocyte homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in hippocampus development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within liver regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to tetrachloromethane ISO
Inferred from Sequence Orthology
more info
  
involved_in subtelomeric heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase EZH1
Names
enhancer of zeste homolog 1
NP_001100521.1
XP_006247380.1
XP_006247381.1
XP_008766274.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107051.1 → NP_001100521.1  histone-lysine N-methyltransferase EZH1

    See identical proteins and their annotated locations for NP_001100521.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HJ95, F1LZH3
    Conserved Domains (5) summary
    COG2940
    Location:463 → 727
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd00167
    Location:433 → 474
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd19217
    Location:608 → 743
    SET_EZH1; SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:159 → 262
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86626307..86662257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247318.5 → XP_006247380.1  histone-lysine N-methyltransferase EZH1 isoform X1

    See identical proteins and their annotated locations for XP_006247380.1

    UniProtKB/TrEMBL
    F1LZH3
    Related
    ENSRNOP00000027640.7
    Conserved Domains (5) summary
    COG2940
    Location:463 → 727
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd00167
    Location:433 → 474
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd19217
    Location:608 → 743
    SET_EZH1; SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:159 → 262
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

  2. XM_008768052.4 → XP_008766274.1  histone-lysine N-methyltransferase EZH1 isoform X1

    See identical proteins and their annotated locations for XP_008766274.1

    UniProtKB/TrEMBL
    F1LZH3
    Conserved Domains (5) summary
    COG2940
    Location:463 → 727
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd00167
    Location:433 → 474
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd19217
    Location:608 → 743
    SET_EZH1; SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:159 → 262
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

  3. XM_006247319.4 → XP_006247381.1  histone-lysine N-methyltransferase EZH1 isoform X1

    See identical proteins and their annotated locations for XP_006247381.1

    UniProtKB/TrEMBL
    F1LZH3
    Conserved Domains (5) summary
    COG2940
    Location:463 → 727
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd00167
    Location:433 → 474
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd19217
    Location:608 → 743
    SET_EZH1; SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:159 → 262
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
Nucleotide Protein Strain
Heading Accession and Version

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