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Rundc3a RUN domain containing 3A [ Rattus norvegicus (Norway rat) ]

Gene ID: 303569, updated on 5-Mar-2024

Summary

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Official Symbol
Rundc3aprovided by RGD
Official Full Name
RUN domain containing 3Aprovided by RGD
Primary source
RGD:735057
See related
Ensembl:ENSRNOG00000020970 AllianceGenome:RGD:735057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GCRP; Rap2ip
Summary
Involved in positive regulation of cGMP-mediated signaling. Located in cytosol and plasma membrane. Orthologous to human RUNDC3A (RUN domain containing 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 324.7), Adrenal (RPKM 23.7) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Rundc3a in Genome Data Viewer
Location:
10q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87852746..87861903)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87352624..87361767)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90342033..90351172)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 member 1 (Diego blood group) Neighboring gene partner of NOB1 homolog (S. cerevisiae), pseudogene 1 Neighboring gene solute carrier family 25, member 39 Neighboring gene granulin precursor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of a regulatory protein for membrane-bound guanylate cyclase GC-A. Chen ZJ, et al. Biochem Biophys Res Commun, 2000 Nov 11. PMID 11071862
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RUN domain-containing protein 3A
Names
Rap2 interacting protein
guanylate-cyclase regulatory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198758.2 → NP_942053.2  RUN domain-containing protein 3A

    Status: VALIDATED

    Source sequence(s)
    BC127472, CB797318, DY319760
    UniProtKB/TrEMBL
    A6HJI9, F1LRZ9
    Related
    ENSRNOP00000028487.2, ENSRNOT00000028487.4
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 186
    RUN; RUN domain
    pfam06785
    Location:238 → 318
    UPF0242; Uncharacterized protein family (UPF0242)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    87852746..87861903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247339.5 → XP_006247401.1  RUN domain-containing protein 3A isoform X11

    UniProtKB/TrEMBL
    A6HJI9
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 186
    RUN; RUN domain
    pfam06785
    Location:238 → 318
    UPF0242; Uncharacterized protein family (UPF0242)

  2. XM_008768058.4 → XP_008766280.1  RUN domain-containing protein 3A isoform X4

    UniProtKB/TrEMBL
    A6HJI9
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 181
    RUN; RUN domain
    pfam06785
    Location:233 → 313
    UPF0242; Uncharacterized protein family (UPF0242)

  3. XM_017597324.3 → XP_017452813.1  RUN domain-containing protein 3A isoform X6

    UniProtKB/TrEMBL
    A0A0G2JW67, A6HJI9
    Related
    ENSRNOP00000069763.2
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 186
    RUN; RUN domain
    pfam06785
    Location:238 → 318
    UPF0242; Uncharacterized protein family (UPF0242)

  4. XM_017597325.3 → XP_017452814.1  RUN domain-containing protein 3A isoform X10

    UniProtKB/TrEMBL
    A6HJI9
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 186
    RUN; RUN domain
    pfam06785
    Location:238 → 318
    UPF0242; Uncharacterized protein family (UPF0242)

  5. XM_006247335.5 → XP_006247397.1  RUN domain-containing protein 3A isoform X2

    See identical proteins and their annotated locations for XP_006247397.1

    UniProtKB/TrEMBL
    A6HJI8, A6HJI9
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 186
    RUN; RUN domain
    pfam06785
    Location:238 → 318
    UPF0242; Uncharacterized protein family (UPF0242)

  6. XM_063269161.1 → XP_063125231.1  RUN domain-containing protein 3A isoform X12

  7. XM_039086113.2 → XP_038942041.1  RUN domain-containing protein 3A isoform X7

    UniProtKB/TrEMBL
    A6HJI9
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 182
    RUN; RUN domain
    pfam06785
    Location:234 → 314
    UPF0242; Uncharacterized protein family (UPF0242)

  8. XM_017597323.3 → XP_017452812.1  RUN domain-containing protein 3A isoform X1

    UniProtKB/TrEMBL
    A1L117
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 181
    RUN; RUN domain
    pfam06785
    Location:233 → 313
    UPF0242; Uncharacterized protein family (UPF0242)

  9. XM_006247340.5 → XP_006247402.1  RUN domain-containing protein 3A isoform X8

    UniProtKB/TrEMBL
    A6HJI9
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 181
    RUN; RUN domain
    pfam06785
    Location:233 → 313
    UPF0242; Uncharacterized protein family (UPF0242)

  10. XM_063269160.1 → XP_063125230.1  RUN domain-containing protein 3A isoform X9

  11. XM_063269162.1 → XP_063125232.1  RUN domain-containing protein 3A isoform X13

  12. XM_063269158.1 → XP_063125228.1  RUN domain-containing protein 3A isoform X3

  13. XM_063269159.1 → XP_063125229.1  RUN domain-containing protein 3A isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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