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Fam20a FAM20A, golgi associated secretory pathway pseudokinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 303635, updated on 13-Apr-2024

Summary

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Official Symbol
Fam20aprovided by RGD
Official Full Name
FAM20A, golgi associated secretory pathway pseudokinaseprovided by RGD
Primary source
RGD:1306364
See related
Ensembl:ENSRNOG00000003969 AllianceGenome:RGD:1306364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306364
Summary
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in calcium ion homeostasis; odontogenesis; and positive regulation of protein phosphorylation. Predicted to act upstream of or within response to bacterium. Predicted to be located in endoplasmic reticulum and extracellular space. Predicted to colocalize with Golgi apparatus. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1G. Orthologous to human FAM20A (FAM20A golgi associated secretory pathway pseudokinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 172.2), Adrenal (RPKM 131.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (95136799..95197176, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (94638836..94697814, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (97962467..98017171, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene arylsulfatase G Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene uncharacterized LOC100912202 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha Neighboring gene uncharacterized LOC134480894 Neighboring gene RIKEN cDNA 1700012B07 gene like Neighboring gene ribosomal protein L23a, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Autosomal recessive gingival hyperplasia and dental anomalies caused by a 29-base pair duplication in the FAM20A gene. Cabral RM, et al. J Hum Genet, 2013 Aug. PMID 23697977
  2. Nephrocalcinosis (enamel renal syndrome) caused by autosomal recessive FAM20A mutations. Jaureguiberry G, et al. Nephron Physiol, 2012. PMID 23434854, Free PMC Article
  3. Novel FAM20A mutations in hypoplastic amelogenesis imperfecta. Cho SH, et al. Hum Mutat, 2012 Jan. PMID 21990045
  4. FAM20A mutations can cause enamel-renal syndrome (ERS). Wang SK, et al. PLoS Genet, 2013. PMID 23468644, Free PMC Article
  5. Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice. Vogel P, et al. Vet Pathol, 2012 Nov. PMID 22732358

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables phosphotransferase activity, alcohol group as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biomineral tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in enamel mineralization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within enamel mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in enamel mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in tooth eruption ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pseudokinase FAM20A
Names
family with sequence similarity 20, member A
protein FAM20A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012237.2 → NP_001012237.1  pseudokinase FAM20A

    See identical proteins and their annotated locations for NP_001012237.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    I7LRF5, J9JIJ5
    Related
    ENSRNOP00000005367.3, ENSRNOT00000005367.6
    Conserved Domains (1) summary
    cl05973
    Location:306 → 522
    FAM20_C_like; C-terminal putative kinase domain of FAM20 (family with sequence similarity 20), Drosophila Four-jointed (Fj), and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    95136799..95197176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086178.2 → XP_038942106.1  pseudokinase FAM20A isoform X1

    Conserved Domains (1) summary
    cl05973
    Location:119 → 335
    FAM20_C_like; C-terminal putative kinase domain of FAM20 (family with sequence similarity 20), Drosophila Four-jointed (Fj), and related proteins

  2. XM_039086179.2 → XP_038942107.1  pseudokinase FAM20A isoform X1

    Conserved Domains (1) summary
    cl05973
    Location:119 → 335
    FAM20_C_like; C-terminal putative kinase domain of FAM20 (family with sequence similarity 20), Drosophila Four-jointed (Fj), and related proteins

RNA

  1. XR_005489861.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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