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Cdc42ep4 CDC42 effector protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303653, updated on 30-Mar-2024

Summary

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Official Symbol
Cdc42ep4provided by RGD
Official Full Name
CDC42 effector protein 4provided by RGD
Primary source
RGD:1311567
See related
Ensembl:ENSRNOG00000028946 AllianceGenome:RGD:1311567
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in Rho protein signal transduction; positive regulation of cellular component biogenesis; and regulation of cell shape. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in adherens junction; cytoskeleton; and phagocytic vesicle. Predicted to be active in cytoplasm; cytoskeleton; and plasma membrane. Orthologous to human CDC42EP4 (CDC42 effector protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 133.8), Adrenal (RPKM 109.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdc42ep4 in Genome Data Viewer
Location:
10q32.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (99271750..99298551, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (98772613..98797924, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (102244680..102269272, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene cleavage and polyadenylation specific factor 4-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC102547853 Neighboring gene sidekick cell adhesion molecule 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. Hirsch DS, et al. J Biol Chem, 2001 Jan 12. PMID 11035016
  2. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Joberty G, et al. Mol Cell Biol, 1999 Oct. PMID 10490598, Free PMC Article
  3. The phagosomal proteome in interferon-gamma-activated macrophages. Trost M, et al. Immunity, 2009 Jan 16. PMID 19144319
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of pseudopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of pseudopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cdc42 effector protein 4
Names
CDC42 effector protein (Rho GTPase binding) 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107063.3 → NP_001100533.1  cdc42 effector protein 4

    See identical proteins and their annotated locations for NP_001100533.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5Y758, B1WC33
    Conserved Domains (2) summary
    pfam00786
    Location:26 → 83
    PBD; P21-Rho-binding domain
    pfam14957
    Location:110 → 219
    BORG_CEP; Cdc42 effector

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    99271750..99298551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086182.2 → XP_038942110.1  cdc42 effector protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y758, B1WC33
    Related
    ENSRNOP00000045828.3
    Conserved Domains (2) summary
    pfam00786
    Location:26 → 83
    PBD; P21-Rho-binding domain
    pfam14957
    Location:110 → 219
    BORG_CEP; Cdc42 effector

  2. XM_006247689.5 → XP_006247751.1  cdc42 effector protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006247751.1

    UniProtKB/TrEMBL
    A0A8I5Y758, B1WC33
    Related
    ENSRNOP00000078041.1
    Conserved Domains (2) summary
    pfam00786
    Location:26 → 83
    PBD; P21-Rho-binding domain
    pfam14957
    Location:110 → 219
    BORG_CEP; Cdc42 effector

  3. XM_006247688.4 → XP_006247750.1  cdc42 effector protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006247750.1

    UniProtKB/TrEMBL
    A0A8I5Y758, B1WC33
    Related
    ENSRNOP00000090992.1
    Conserved Domains (2) summary
    pfam00786
    Location:26 → 83
    PBD; P21-Rho-binding domain
    pfam14957
    Location:110 → 219
    BORG_CEP; Cdc42 effector

  4. XM_039086181.2 → XP_038942109.1  cdc42 effector protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y758, B1WC33
    Conserved Domains (2) summary
    pfam00786
    Location:26 → 83
    PBD; P21-Rho-binding domain
    pfam14957
    Location:110 → 219
    BORG_CEP; Cdc42 effector

  5. XM_006247690.5 → XP_006247752.1  cdc42 effector protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006247752.1

    UniProtKB/TrEMBL
    A0A8I5Y758, B1WC33
    Related
    ENSRNOP00000077095.1
    Conserved Domains (2) summary
    pfam00786
    Location:26 → 83
    PBD; P21-Rho-binding domain
    pfam14957
    Location:110 → 219
    BORG_CEP; Cdc42 effector
Nucleotide Protein Strain
Heading Accession and Version

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