Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Enpp7provided by RGD
Official Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 7provided by RGD
Primary source: RGD:1359324
See related: AllianceGenome:RGD:1359324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: E-NPP 7
Summary: Enables sphingomyelin phosphodiesterase activity. Predicted to be involved in several processes, including fatty acid homeostasis; positive regulation of intestinal cholesterol absorption; and regulation of membrane lipid metabolic process. Predicted to be located in Golgi apparatus and microvillus. Predicted to be integral component of plasma membrane. Orthologous to human ENPP7 (ectonucleotide pyrophosphatase/phosphodiesterase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (104740763..104745760)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (104242169..104247185)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (108095131..108099483)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The presence of bile salts is important for maintaining high intraluminal levels of Alk-SMase and N-CDase, two key enzymes for hydrolysis of sphingomyelin in the gut.
Title: Effects of bile diversion in rats on intestinal sphingomyelinases and ceramidase.
Results describe the cloning of rat alkaline sphingomyelinase from rat intestine, comparison to the human sequence, adjustment of the putative protein in GenBank, and confirmation of the specific expression of the gene in the small intestine.
Title: Cloning of alkaline sphingomyelinase from rat intestinal mucosa and adjusting of the hypothetical protein XP_221184 in GenBank.
Alkaline sphingomyelinase hydrolyses and inactivates PAF by a phospholipase C activity, a novel function by which it may counteract the development of intestinal inflammation and colon cancer.
Title: Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphoric diester hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoric diester hydrolase activity	ISO Inferred from Sequence Orthology more info
enables sphingomyelin phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables sphingomyelin phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables sphingomyelin phosphodiesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in fatty acid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in fatty acid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid digestion	ISO Inferred from Sequence Orthology more info
involved_in lipid digestion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ceramide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intestinal cholesterol absorption	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intestinal cholesterol absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sphingomyelin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sphingomyelin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of intestinal lipid absorption	ISO Inferred from Sequence Orthology more info
involved_in regulation of intestinal lipid absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in sphingomyelin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sphingomyelin metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ectonucleotide pyrophosphatase/phosphodiesterase family member 7

Names: E-NPP7; NPP-7; alk-SMase; alkaline sphingomyelin phosphodiesterase; intestinal alkaline sphingomyelinase; sphingomyelinase, intestinal alkaline

NP_001012484.2

EC 3.1.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012466.3 → NP_001012484.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q5EZ72

Conserved Domains (1) summary

cd16018
Location:30 → 395

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin