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Rnf213 ring finger protein 213 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303735, updated on 13-Apr-2024

Summary

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Official Symbol
Rnf213provided by RGD
Official Full Name
ring finger protein 213provided by RGD
Primary source
RGD:1308168
See related
Ensembl:ENSRNOG00000029658 AllianceGenome:RGD:1308168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308168
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in several processes, including cellular protein metabolic process; protein homooligomerization; and sprouting angiogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleolus. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human RNF213 (ring finger protein 213). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 413.6), Adrenal (RPKM 287.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.3
Exon count:
71
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (105154873..105254148)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (104656329..104755669)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (108527351..108626372)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family, member 14 Neighboring gene N-sulfoglucosamine sulfohydrolase Neighboring gene solute carrier family 26 member 11 Neighboring gene uncharacterized LOC120095223 Neighboring gene endonuclease V Neighboring gene uncharacterized LOC103693491

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transient Global Cerebral Ischemia Induces RNF213, a Moyamoya Disease Susceptibility Gene, in Vulnerable Neurons of the Rat Hippocampus CA1 Subregion and Ischemic Cortex. Sato-Maeda M, et al. J Stroke Cerebrovasc Dis, 2017 Sep. PMID 28734662
  2. Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells. Ohkubo K, et al. Sci Rep, 2015 Aug 17. PMID 26278786, Free PMC Article
  3. Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA+ ATPase, which dynamically changes its oligomeric state. Morito D, et al. Sci Rep, 2014 Mar 24. PMID 24658080, Free PMC Article
  4. Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo. Kobayashi H, et al. J Am Heart Assoc, 2015 Jun 30. PMID 26126547, Free PMC Article
  5. Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. Liu W, et al. PLoS One, 2011. PMID 21799892, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel signaling axis of FHOD1-RNF213-Col1alpha/Col3alpha in the pathogenesis of hypertension-induced tunica media thickening.
    Title: Novel signaling axis of FHOD1-RNF213-Col1α/Col3α in the pathogenesis of hypertension-induced tunica media thickening.
  2. Report up-regulation of the Rnf213 gene in vulnerable neurons in the hippocampus CA1 after transient global cerebral ischemia.
    Title: Transient Global Cerebral Ischemia Induces RNF213, a Moyamoya Disease Susceptibility Gene, in Vulnerable Neurons of the Rat Hippocampus CA1 Subregion and Ischemic Cortex.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of non-canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF213
Names
protein ALO17
NP_001414610.1
XP_038943469.1
XP_038943470.1
XP_038943471.1
XP_063125317.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427681.1 → NP_001414610.1  E3 ubiquitin-protein ligase RNF213

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6AKP6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    105154873..105254148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087541.2 → XP_038943469.1  E3 ubiquitin-protein ligase RNF213 isoform X1

    UniProtKB/TrEMBL
    F1M0R1
    Conserved Domains (5) summary
    smart00382
    Location:2427 → 2549
    AAA; ATPases associated with a variety of cellular activities
    COG5574
    Location:3931 → 4039
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:4000 → 4038
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam12773
    Location:3 → 29
    DZR; Double zinc ribbon
    cl17238
    Location:4000 → 4039
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_039087542.2 → XP_038943470.1  E3 ubiquitin-protein ligase RNF213 isoform X2

    UniProtKB/TrEMBL
    F1M0R1
    Conserved Domains (5) summary
    smart00382
    Location:2427 → 2549
    AAA; ATPases associated with a variety of cellular activities
    COG5574
    Location:3930 → 4038
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:3999 → 4037
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam12773
    Location:3 → 29
    DZR; Double zinc ribbon
    cl17238
    Location:3999 → 4038
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_039087543.2 → XP_038943471.1  E3 ubiquitin-protein ligase RNF213 isoform X3

    UniProtKB/TrEMBL
    F1M0R1
    Related
    ENSRNOP00000095018.1
    Conserved Domains (5) summary
    smart00382
    Location:2384 → 2506
    AAA; ATPases associated with a variety of cellular activities
    COG5574
    Location:3888 → 3996
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:3957 → 3995
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam12773
    Location:3 → 29
    DZR; Double zinc ribbon
    cl17238
    Location:3957 → 3996
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  4. XM_063269247.1 → XP_063125317.1  E3 ubiquitin-protein ligase RNF213 isoform X1

RNA

  1. XR_005490584.2 RNA Sequence

  2. XR_005490583.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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