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Klhl24 kelch-like family member 24 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303803, updated on 13-Apr-2024

Summary

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Official Symbol
Klhl24provided by RGD
Official Full Name
kelch-like family member 24provided by RGD
Primary source
RGD:727971
See related
Ensembl:ENSRNOG00000033372 AllianceGenome:RGD:727971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dre1
Summary
Predicted to be involved in intermediate filament organization and protein autoubiquitination. Predicted to be located in adherens junction; cytoplasm; and desmosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human KLHL24 (kelch like family member 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 826.4), Heart (RPKM 740.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhl24 in Genome Data Viewer
Location:
11q23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (94348024..94382085, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80843621..80877649, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (84613101..84643674, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene MAP6 domain containing 1 Neighboring gene YEATS domain containing 2 Neighboring gene transfer RNA threonine (anticodon AGU) 24 Neighboring gene kelch-like family member 6 Neighboring gene EWS RNA-binding protein 5 Neighboring gene EWS RNA-binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Monoallelic Mutations in the Translation Initiation Codon of KLHL24 Cause Skin Fragility. He Y, et al. Am J Hum Genet, 2016 Dec 1. PMID 27889062, Free PMC Article
  2. Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility. Lin Z, et al. Nat Genet, 2016 Dec. PMID 27798626
  3. KRIP6: a novel BTB/kelch protein regulating function of kainate receptors. Laezza F, et al. Mol Cell Neurosci, 2007 Apr. PMID 17254796, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a novel neuronal protein of the BTB/kelch family, KRIP6.
    Title: KRIP6: a novel BTB/kelch protein regulating function of kainate receptors.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC105289

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in intermediate filament organization IEA
Inferred from Electronic Annotation
more info
  
involved_in intermediate filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autoubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in desmosome IEA
Inferred from Electronic Annotation
more info
  
located_in desmosome ISO
Inferred from Sequence Orthology
more info
  
located_in desmosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kelch-like protein 24
Names
KRIP6
kainate receptor-interacting protein for GluR6
kelch-like 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394229.1 → NP_001381158.1  kelch-like protein 24

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q56A24, Q812D9
    UniProtKB/TrEMBL
    A6JSC2, F1LNL5
    Related
    ENSRNOP00000050815.6, ENSRNOT00000052120.6
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

  2. NM_181473.3 → NP_852138.2  kelch-like protein 24

    See identical proteins and their annotated locations for NP_852138.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q56A24, Q812D9
    UniProtKB/TrEMBL
    A6JSC2, F1LNL5
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    94348024..94382085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270472.1 → XP_063126542.1  kelch-like protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q56A24, Q812D9
    UniProtKB/TrEMBL
    A6JSC2

  2. XM_039088275.2 → XP_038944203.1  kelch-like protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q56A24, Q812D9
    UniProtKB/TrEMBL
    A6JSC2, F1LNL5
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

  3. XM_063270469.1 → XP_063126539.1  kelch-like protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q56A24, Q812D9
    UniProtKB/TrEMBL
    A6JSC2

  4. XM_063270473.1 → XP_063126543.1  kelch-like protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q56A24, Q812D9
    UniProtKB/TrEMBL
    A6JSC2

  5. XM_063270470.1 → XP_063126540.1  kelch-like protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q56A24, Q812D9
    UniProtKB/TrEMBL
    A6JSC2

  6. XM_063270471.1 → XP_063126541.1  kelch-like protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q56A24, Q812D9
    UniProtKB/TrEMBL
    A6JSC2

  7. XM_039088276.2 → XP_038944204.1  kelch-like protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q56A24, Q812D9
    UniProtKB/TrEMBL
    A6JSC2, F1LNL5
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56A24.1 GenPept UniProtKB/Swiss-Prot:Q56A24

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