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Parp9 poly (ADP-ribose) polymerase family, member 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303905, updated on 11-Apr-2024

Summary

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Official Symbol
Parp9provided by RGD
Official Full Name
poly (ADP-ribose) polymerase family, member 9provided by RGD
Primary source
RGD:1307534
See related
Ensembl:ENSRNOG00000023463 AllianceGenome:RGD:1307534
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307534
Summary
Predicted to enable several functions, including ADP-D-ribose binding activity; STAT family protein binding activity; and pentosyltransferase activity. Predicted to be involved in several processes, including protein ADP-ribosylation; regulation of defense response; and regulation of gene expression. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and site of DNA damage. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human PARP9 (poly(ADP-ribose) polymerase family member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 249.3), Spleen (RPKM 170.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Parp9 in Genome Data Viewer
Location:
11q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (78286282..78320409, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (64780977..64814995, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (67724071..67758027, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 5B Neighboring gene karyopherin subunit alpha 1 Neighboring gene uncharacterized LOC134481077 Neighboring gene deltex E3 ubiquitin ligase 3L Neighboring gene caspase 6, pseudogene 1 Neighboring gene poly (ADP-ribose) polymerase family, member 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. Juszczynski P, et al. Mol Cell Biol, 2006 Jul. PMID 16809771, Free PMC Article
  2. Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9. Yang CS, et al. Mol Cell, 2017 May 18. PMID 28525742, Free PMC Article
  3. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. Aguiar RC, et al. J Biol Chem, 2005 Oct 7. PMID 16061477
  4. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. Iwata H, et al. Nat Commun, 2016 Oct 31. PMID 27796300, Free PMC Article
  5. BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. Yan Q, et al. Mol Cell Biol, 2013 Feb. PMID 23230272, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC156739

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ADP-D-ribose binding ISO
Inferred from Sequence Orthology
more info
  
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables NAD+ binding ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables STAT family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of type II interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
involved_in post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in protein poly-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase PARP9
Names
poly [ADP-ribose] polymerase 9
NP_001096821.1
XP_017453484.1
XP_017453485.1
XP_038944271.1
XP_038944274.1
XP_038944275.1
XP_038944279.1
XP_063126587.1
XP_063126588.1
XP_063126589.1
XP_063126590.1
XP_063126591.1
XP_063126592.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103351.2 → NP_001096821.1  protein mono-ADP-ribosyltransferase PARP9

    See identical proteins and their annotated locations for NP_001096821.1

    Status: PROVISIONAL

    Source sequence(s)
    BC128756
    UniProtKB/TrEMBL
    A1A5Q1, A6IRE6, F1MAR0
    Conserved Domains (3) summary
    cd01439
    Location:673 → 792
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02907
    Location:83 → 243
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00019
    Location:280 → 455
    Macro_SF; macrodomain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    78286282..78320409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270517.1 → XP_063126587.1  protein mono-ADP-ribosyltransferase PARP9 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AD67

  2. XM_039088346.2 → XP_038944274.1  protein mono-ADP-ribosyltransferase PARP9 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y6A7, A0A8J8Y5V1
    Conserved Domains (3) summary
    cd01439
    Location:709 → 828
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02907
    Location:119 → 279
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00019
    Location:316 → 491
    Macro_SF; macrodomain superfamily

  3. XM_017597995.3 → XP_017453484.1  protein mono-ADP-ribosyltransferase PARP9 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y6A7, A0A8J8Y5V1
    Conserved Domains (3) summary
    cd01439
    Location:709 → 828
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02907
    Location:119 → 279
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00019
    Location:316 → 491
    Macro_SF; macrodomain superfamily

  4. XM_039088347.2 → XP_038944275.1  protein mono-ADP-ribosyltransferase PARP9 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y6A7, A0A8J8Y5V1
    Conserved Domains (3) summary
    cd01439
    Location:709 → 828
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02907
    Location:119 → 279
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00019
    Location:316 → 491
    Macro_SF; macrodomain superfamily

  5. XM_017597996.3 → XP_017453485.1  protein mono-ADP-ribosyltransferase PARP9 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y6A7, A0A8J8Y5V1
    Conserved Domains (3) summary
    cd01439
    Location:709 → 828
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02907
    Location:119 → 279
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00019
    Location:316 → 491
    Macro_SF; macrodomain superfamily

  6. XM_063270519.1 → XP_063126589.1  protein mono-ADP-ribosyltransferase PARP9 isoform X2

    UniProtKB/TrEMBL
    A0A8J8Y5V1

  7. XM_063270518.1 → XP_063126588.1  protein mono-ADP-ribosyltransferase PARP9 isoform X2

    UniProtKB/TrEMBL
    A0A8J8Y5V1

  8. XM_063270521.1 → XP_063126591.1  protein mono-ADP-ribosyltransferase PARP9 isoform X5

    UniProtKB/TrEMBL
    A6IRE8

  9. XM_039088351.2 → XP_038944279.1  protein mono-ADP-ribosyltransferase PARP9 isoform X3

    UniProtKB/TrEMBL
    A1A5Q1, A6IRE6, F1MAR0
    Conserved Domains (3) summary
    cd01439
    Location:673 → 792
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02907
    Location:83 → 243
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00019
    Location:280 → 455
    Macro_SF; macrodomain superfamily

  10. XM_063270522.1 → XP_063126592.1  protein mono-ADP-ribosyltransferase PARP9 isoform X5

    UniProtKB/TrEMBL
    A6IRE8

  11. XM_039088343.2 → XP_038944271.1  protein mono-ADP-ribosyltransferase PARP9 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y6A7, A0A8J8Y5V1
    Conserved Domains (3) summary
    cd01439
    Location:709 → 828
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02907
    Location:119 → 279
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00019
    Location:316 → 491
    Macro_SF; macrodomain superfamily

  12. XM_063270520.1 → XP_063126590.1  protein mono-ADP-ribosyltransferase PARP9 isoform X4

RNA

  1. XR_010055954.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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