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Usp25 ubiquitin specific peptidase 25 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304150, updated on 11-Apr-2024

Summary

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Symbol
Usp25provided by RGD
Full Name
ubiquitin specific peptidase 25provided by RGD
Primary source
RGD:1309003
See related
Ensembl:ENSRNOG00000001573 AllianceGenome:RGD:1309003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SUMO binding activity; cysteine-type peptidase activity; and enzyme binding activity. Predicted to be involved in several processes, including interleukin-17-mediated signaling pathway; intracellular signal transduction; and protein deubiquitination. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. Orthologous to human USP25 (ubiquitin specific peptidase 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 349.5), Spleen (RPKM 266.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Usp25 in Genome Data Viewer
Location:
11p11-q11
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (29088283..29198323)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (15603654..15711356)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (15436080..15558646)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556241 Neighboring gene uncharacterized LOC102548078 Neighboring gene uncharacterized LOC120095594 Neighboring gene uncharacterized LOC134481049 Neighboring gene uncharacterized LOC103693508 Neighboring gene uncharacterized LOC134481048

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Altered gene expression levels of IL-17/TRAF6/MAPK/USP25 axis and pro-inflammatory cytokine levels in lung tissue of obese ovalbumin-sensitized rats. Aslani MR, et al. Life Sci, 2022 May 1. PMID 35202642
  2. Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation. Blount JR, et al. PLoS One, 2012. PMID 22590560, Free PMC Article
  3. Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. Meulmeester E, et al. Mol Cell, 2008 Jun 6. PMID 18538659
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitin-specific peptidase 25 exacerbated osteoarthritis progression through facilitating TXNIP ubiquitination and NLRP3 inflammasome activation.
    Title: Ubiquitin-specific peptidase 25 exacerbated osteoarthritis progression through facilitating TXNIP ubiquitination and NLRP3 inflammasome activation.
  2. Altered gene expression levels of IL-17/TRAF6/MAPK/USP25 axis and pro-inflammatory cytokine levels in lung tissue of obese ovalbumin-sensitized rats.
    Title: Altered gene expression levels of IL-17/TRAF6/MAPK/USP25 axis and pro-inflammatory cytokine levels in lung tissue of obese ovalbumin-sensitized rats.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables SUMO binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-17-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-17-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-17-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-activated protein kinase signaling cascade ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 25
Names
ubiquitin carboxyl-terminal hydrolase 25-like
ubiquitin specific protease 25
NP_001100584.1
XP_063126672.1
XP_063126673.1
XP_063126674.1
XP_063126675.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107114.2 → NP_001100584.1  ubiquitin carboxyl-terminal hydrolase 25

    See identical proteins and their annotated locations for NP_001100584.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A0G2JZL5, A6JL28, D4ACD3
    Related
    ENSRNOP00000002150.4, ENSRNOT00000002150.7
    Conserved Domains (3) summary
    cd02665
    Location:171 → 656
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14354
    Location:15 → 60
    UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
    pfam00443
    Location:169 → 406
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    29088283..29198323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270605.1 → XP_063126675.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X4

  2. XM_063270602.1 → XP_063126672.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZPF8

  3. XM_063270604.1 → XP_063126674.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X3

  4. XM_063270603.1 → XP_063126673.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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