U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pds5b PDS5 cohesin associated factor B [ Rattus norvegicus (Norway rat) ]

Gene ID: 304218, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Pds5bprovided by RGD
Official Full Name
PDS5 cohesin associated factor Bprovided by RGD
Primary source
RGD:1310838
See related
Ensembl:ENSRNOG00000001098 AllianceGenome:RGD:1310838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AS3; Aprin; CG008
Summary
Predicted to enable DNA binding activity. Involved in negative regulation of cell population proliferation. Located in nucleus. Orthologous to human PDS5B (PDS5 cohesin associated factor B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 136.9), Brain (RPKM 125.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12p12
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (5038114..5181208)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (202481..345596)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (659995..794042)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene BRCA2, DNA repair associated Neighboring gene NEDD4 binding protein 2-like 1 Neighboring gene NEDD4 binding protein 2-like 2 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120095865 Neighboring gene uncharacterized LOC102548900

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mechanism of androgen action on cell proliferation: AS3 protein as a mediator of proliferative arrest in the rat prostate. Maffini MV, et al. Endocrinology, 2002 Jul. PMID 12072405
  2. Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator. Geck P, et al. Proc Natl Acad Sci U S A, 2000 Aug 29. PMID 10963680, Free PMC Article
  3. Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. Zhang B, et al. PLoS One, 2009. PMID 19412548, Free PMC Article
  4. Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. Losada A, et al. J Cell Sci, 2005 May 15. PMID 15855230
  5. Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Watrin E, et al. Curr Biol, 2006 May 9. PMID 16682347

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AS3 is a mediator of the proliferative arrest in the normal rat prostate in situ and that its expression is androgen-induced (AS3 protein)
    Title: Mechanism of androgen action on cell proliferation: AS3 protein as a mediator of proliferative arrest in the rat prostate.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ23236, KIAA0979

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lens development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid cohesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IEA
Inferred from Electronic Annotation
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sister chromatid cohesion protein PDS5 homolog B
Names
PDS5, regulator of cohesion maintenance, homolog B
androgen-induced prostate proliferative shutoff associated protein
androgen-induced prostate proliferative shutoff-associated protein AS3
androgen-induced shutoff 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101805.1 → NP_001095275.1  sister chromatid cohesion protein PDS5 homolog B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks alternate in-frame segments in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    CK357543, JAXUCZ010000012
    UniProtKB/TrEMBL
    D3ZU56, D3ZXE2
    Related
    ENSRNOP00000001464.5, ENSRNOT00000001464.8
    Conserved Domains (2) summary
    pfam05793
    Location:1168 → 1384
    TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
    sd00044
    Location:240 → 261
    HEAT; HEAT repeat [structural motif]

  2. NM_001102383.2 → NP_001095853.1  sister chromatid cohesion protein PDS5 homolog B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    CK357543, JAXUCZ010000012
    UniProtKB/TrEMBL
    D3ZXE2, F1M797
    Related
    ENSRNOP00000040297.6, ENSRNOT00000050733.7
    Conserved Domains (2) summary
    pfam05793
    Location:1211 → 1421
    TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
    sd00044
    Location:240 → 261
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    5038114..5181208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089323.2 → XP_038945251.1  sister chromatid cohesion protein PDS5 homolog B isoform X4

    UniProtKB/TrEMBL
    A0A8I6GK18, D3ZXE2
    Conserved Domains (3) summary
    PTZ00121
    Location:1196 → 1432
    PTZ00121; MAEBL; Provisional
    sd00044
    Location:240 → 261
    HEAT; HEAT repeat [structural motif]
    cd19953
    Location:31 → 661
    PDS5; Sister chromatid cohesion protein PDS5

  2. XM_039089324.1 → XP_038945252.1  sister chromatid cohesion protein PDS5 homolog B isoform X4

    UniProtKB/TrEMBL
    A0A8I6GK18, D3ZXE2
    Conserved Domains (3) summary
    PTZ00121
    Location:1196 → 1432
    PTZ00121; MAEBL; Provisional
    sd00044
    Location:240 → 261
    HEAT; HEAT repeat [structural motif]
    cd19953
    Location:31 → 661
    PDS5; Sister chromatid cohesion protein PDS5

  3. XM_063271248.1 → XP_063127318.1  sister chromatid cohesion protein PDS5 homolog B isoform X4

    UniProtKB/TrEMBL
    A0A8I6GK18

  4. XM_039089322.2 → XP_038945250.1  sister chromatid cohesion protein PDS5 homolog B isoform X4

    UniProtKB/TrEMBL
    A0A8I6GK18, D3ZXE2
    Related
    ENSRNOP00000092974.1
    Conserved Domains (3) summary
    PTZ00121
    Location:1196 → 1432
    PTZ00121; MAEBL; Provisional
    sd00044
    Location:240 → 261
    HEAT; HEAT repeat [structural motif]
    cd19953
    Location:31 → 661
    PDS5; Sister chromatid cohesion protein PDS5

  5. XM_039089319.1 → XP_038945247.1  sister chromatid cohesion protein PDS5 homolog B isoform X1

    UniProtKB/Swiss-Prot
    Q5G5U1, Q5G6V7, Q5G6V8, Q5PY35, Q5PY36, Q6TRW4
    UniProtKB/TrEMBL
    D3ZXE2
    Conserved Domains (3) summary
    PTZ00121
    Location:1196 → 1431
    PTZ00121; MAEBL; Provisional
    sd00044
    Location:240 → 261
    HEAT; HEAT repeat [structural motif]
    cd19953
    Location:31 → 661
    PDS5; Sister chromatid cohesion protein PDS5

  6. XM_039089325.1 → XP_038945253.1  sister chromatid cohesion protein PDS5 homolog B isoform X5

    UniProtKB/TrEMBL
    D3ZXE2
    Conserved Domains (3) summary
    PTZ00121
    Location:1196 → 1395
    PTZ00121; MAEBL; Provisional
    sd00044
    Location:240 → 261
    HEAT; HEAT repeat [structural motif]
    cd19953
    Location:31 → 661
    PDS5; Sister chromatid cohesion protein PDS5

  7. XM_039089320.1 → XP_038945248.1  sister chromatid cohesion protein PDS5 homolog B isoform X2

    UniProtKB/TrEMBL
    D3ZXE2
    Conserved Domains (3) summary
    sd00044
    Location:240 → 261
    HEAT; HEAT repeat [structural motif]
    pfam05793
    Location:1175 → 1417
    TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
    cd19953
    Location:31 → 661
    PDS5; Sister chromatid cohesion protein PDS5

  8. XM_039089321.1 → XP_038945249.1  sister chromatid cohesion protein PDS5 homolog B isoform X3

    UniProtKB/TrEMBL
    D3ZXE2
    Conserved Domains (3) summary
    sd00044
    Location:240 → 261
    HEAT; HEAT repeat [structural motif]
    pfam05793
    Location:1175 → 1416
    TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
    cd19953
    Location:31 → 661
    PDS5; Sister chromatid cohesion protein PDS5

  9. XM_039089328.1 → XP_038945256.1  sister chromatid cohesion protein PDS5 homolog B isoform X6

    UniProtKB/TrEMBL
    A0A8I6GAU9, D3ZXE2
    Related
    ENSRNOP00000083511.1, ENSRNOT00000107387.1
    Conserved Domains (3) summary
    sd00044
    Location:240 → 261
    HEAT; HEAT repeat [structural motif]
    pfam05793
    Location:1175 → 1396
    TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
    cd19953
    Location:31 → 661
    PDS5; Sister chromatid cohesion protein PDS5

RNA

  1. XR_010056381.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TRW4.2 GenPept UniProtKB/Swiss-Prot:Q6TRW4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous