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Rnf6 ring finger protein 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304271, updated on 4-Apr-2024

Summary

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Official Symbol
Rnf6provided by RGD
Official Full Name
ring finger protein 6provided by RGD
Primary source
RGD:1306092
See related
Ensembl:ENSRNOG00000000968 AllianceGenome:RGD:1306092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity; androgen receptor binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein polyubiquitination; regulation of androgen receptor signaling pathway; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within negative regulation of axon extension. Predicted to be located in PML body; axon; and nuclear membrane. Predicted to be active in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in esophageal cancer and squamous cell carcinoma. Orthologous to human RNF6 (ring finger protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 153.4), Muscle (RPKM 153.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf6 in Genome Data Viewer
Location:
12p11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (13929160..13940663)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (8816797..8826870)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (10574168..10583196)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095890 Neighboring gene histidine triad nucleotide binding protein 1 like 2 Neighboring gene cyclin-dependent kinase 8 Neighboring gene uncharacterized LOC120095930 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats. Liu B, et al. Brain Behav, 2020 Dec. PMID 32955171, Free PMC Article
  2. Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma. Lo HS, et al. Cancer Res, 2002 Aug 1. PMID 12154016
  3. RNF6 facilitates metastasis and radioresistance in hepatocellular carcinoma through ubiquitination of FoxA1. Cai J, et al. Exp Cell Res, 2019 Jan 1. PMID 30496760
  4. Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell. Lopez P, et al. Mol Cell Biol, 2002 May. PMID 11971979, Free PMC Article
  5. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Xu K, et al. Cancer Cell, 2009 Apr 7. PMID 19345326, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats.
    Title: Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K27-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF6
Names
ring finger protein (C3H2C3 type) 6
NP_001100588.1
XP_038945266.1
XP_038945267.1
XP_063127321.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107118.3 → NP_001100588.1  E3 ubiquitin-protein ligase RNF6

    See identical proteins and their annotated locations for NP_001100588.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A0U1RRV4, A6K1D2, A6K1D4
    Related
    ENSRNOP00000075825.2, ENSRNOT00000092401.2
    Conserved Domains (2) summary
    cd00162
    Location:615 → 655
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:613 → 657
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    13929160..13940663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271251.1 → XP_063127321.1  E3 ubiquitin-protein ligase RNF6 isoform X1

    UniProtKB/TrEMBL
    D3ZRG6

  2. XM_039089339.2 → XP_038945267.1  E3 ubiquitin-protein ligase RNF6 isoform X2

    UniProtKB/TrEMBL
    A0A0U1RRV4, A6K1D2, A6K1D4
    Conserved Domains (2) summary
    cd00162
    Location:615 → 655
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:613 → 657
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_039089338.2 → XP_038945266.1  E3 ubiquitin-protein ligase RNF6 isoform X2

    UniProtKB/TrEMBL
    A0A0U1RRV4, A6K1D2, A6K1D4
    Conserved Domains (2) summary
    cd00162
    Location:615 → 655
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:613 → 657
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version

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