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Mmd2 monocyte to macrophage differentiation-associated 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304301, updated on 5-Mar-2024

Summary

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Official Symbol
Mmd2provided by RGD
Official Full Name
monocyte to macrophage differentiation-associated 2provided by RGD
Primary source
RGD:1306506
See related
Ensembl:ENSRNOG00000001113 AllianceGenome:RGD:1306506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase activity. Predicted to be involved in several processes, including positive regulation of Ras protein signal transduction; positive regulation of neuron differentiation; and positive regulation of protein kinase activity. Predicted to be located in perinuclear region of cytoplasm. Orthologous to human MMD2 (monocyte to macrophage differentiation associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 427.6), Brain (RPKM 279.1) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
12p11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (17075870..17123255)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (11962733..12009776)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (14021724..14078121)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 29 member 4 Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene Rap associating with DIL domain Neighboring gene poly(A) polymerase beta Neighboring gene adaptor related protein complex 5 subunit zeta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Jin T, et al. Cell Res, 2012 Apr. PMID 21968647, Free PMC Article
  2. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Kang P, et al. Neuron, 2012 Apr 12. PMID 22500632, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pore-forming activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
monocyte to macrophage differentiation factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037217.1 → NP_001032294.1  monocyte to macrophage differentiation factor 2

    See identical proteins and their annotated locations for NP_001032294.1

    Status: VALIDATED

    Source sequence(s)
    BE096281, CB579379, CB748602, CO400908, CO404759, CO405970
    UniProtKB/TrEMBL
    A0A8I6ABL5, B1WBN0, F7F9F5
    Related
    ENSRNOP00000057341.2, ENSRNOT00000060608.4
    Conserved Domains (1) summary
    cl03831
    Location:35 → 235
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    17075870..17123255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271263.1 → XP_063127333.1  monocyte to macrophage differentiation factor 2 isoform X1

  2. XM_063271264.1 → XP_063127334.1  monocyte to macrophage differentiation factor 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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