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Ap4m1 adaptor related protein complex 4 subunit mu 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304344, updated on 2-May-2024

Summary

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Official Symbol
Ap4m1provided by RGD
Official Full Name
adaptor related protein complex 4 subunit mu 1provided by RGD
Primary source
RGD:1310233
See related
Ensembl:ENSRNOG00000001353 AllianceGenome:RGD:1310233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein domain specific binding activity. Predicted to be involved in post-Golgi vesicle-mediated transport; protein localization to basolateral plasma membrane; and protein targeting to lysosome. Predicted to be located in early endosome. Predicted to be part of AP-4 adaptor complex. Predicted to be active in cytoplasmic vesicle and trans-Golgi network. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Orthologous to human AP4M1 (adaptor related protein complex 4 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 97.2), Adrenal (RPKM 88.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (22163474..22171734)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (17049766..17055954)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (19314222..19320339)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene microRNA 106b Neighboring gene minichromosome maintenance complex component 7 Neighboring gene microRNA 93 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene metallo-beta-lactamase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. AP4M1 is abnormally expressed in oxygen-glucose deprived hippocampal neurons. Zhang J, et al. Neurosci Lett, 2014 Mar 20. PMID 24486887
  2. Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Burgos PV, et al. Dev Cell, 2010 Mar 16. PMID 20230749, Free PMC Article
  3. AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells. Simmen T, et al. Nat Cell Biol, 2002 Feb. PMID 11802162
  4. Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4. Aguilar RC, et al. J Biol Chem, 2001 Apr 20. PMID 11139587
  5. Association between Rare Variants in AP4E1, a Component of Intracellular Trafficking, and Persistent Stuttering. Raza MH, et al. Am J Hum Genet, 2015 Nov 5. PMID 26544806, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC156474

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi to endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in Golgi to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi to lysosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting to lysosome ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-4 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of AP-4 adaptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
AP-4 complex subunit mu-1
Names
AP-4 adapter complex mu subunit
AP-4 adaptor complex mu subunit
adapter-related protein complex 4 mu-1 subunit
adapter-related protein complex 4 subunit mu-1
adaptor-related protein complex 4, mu 1 subunit
adaptor-related protein complex AP-4, mu 1
mu subunit of AP-4
mu-ARP2
mu-adaptin-related protein 2
mu4
mu4-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037977.3 → NP_001033066.1  AP-4 complex subunit mu-1 isoform 1

    See identical proteins and their annotated locations for NP_001033066.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q2PWT8
    UniProtKB/TrEMBL
    A0A8I6B231, A6KST1
    Related
    ENSRNOP00000001827.2, ENSRNOT00000001827.5
    Conserved Domains (2) summary
    cl02092
    Location:1 → 130
    Clat_adaptor_s; Clathrin adaptor complex small chain
    cd09253
    Location:175 → 453
    AP-4_Mu4_Cterm; C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4

  2. NM_001413271.2 → NP_001400200.1  AP-4 complex subunit mu-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    22163474..22171734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271278.1 → XP_063127348.1  AP-4 complex subunit mu-1 isoform X3

  2. XM_006249008.4 → XP_006249070.1  AP-4 complex subunit mu-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6B231
    Conserved Domains (2) summary
    cl02092
    Location:1 → 130
    Clat_adaptor_s; Clathrin adaptor complex small chain
    cd09253
    Location:175 → 457
    AP-4_Mu4_Cterm; C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4

  3. XM_039089411.2 → XP_038945339.1  AP-4 complex subunit mu-1 isoform X2

    Conserved Domains (1) summary
    cd09253
    Location:47 → 329
    AP-4_Mu4_Cterm; C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2PWT8.1 GenPept UniProtKB/Swiss-Prot:Q2PWT8

Gene LinkOut

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