U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zcwpw1 zinc finger CW-type and PWWP domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304368, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Symbol
Zcwpw1provided by RGD
Full Name
zinc finger CW-type and PWWP domain containing 1provided by RGD
Primary source
RGD:1305405
See related
Ensembl:ENSRNOG00000052199 AllianceGenome:RGD:1305405
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566138
Summary
Predicted to enable methyl-CpG binding activity and methylated histone binding activity. Predicted to be involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Predicted to act upstream of or within homologous chromosome pairing at meiosis. Predicted to be located in XY body and nucleus. Orthologous to human ZCWPW1 (zinc finger CW-type and PWWP domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 66.5), Testes (RPKM 61.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zcwpw1 in Genome Data Viewer
Location:
12q12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24517428..24547942, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (18880625..18910713, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (21418874..21450617, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene RAP1B, member of RAS oncogene family, pseudogene 3 Neighboring gene paired immunoglobin like type 2 receptor beta 2 like 7 Neighboring gene paired immunoglobulin-like type 2 receptor alpha-like Neighboring gene methylphosphate capping enzyme Neighboring gene protein phosphatase 1, regulatory subunit 35 Neighboring gene sperm acrosome developmental regulator

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
Inferred from Sequence Orthology
more info
  
involved_in homologous chromosome pairing at meiosis ISO
Inferred from Sequence Orthology
more info
  
involved_in meiosis I ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in XY body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger CW-type PWWP domain protein 1
Names
zinc finger, CW-type with PWWP domain 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    24517428..24547942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090046.2 → XP_038945974.1  zinc finger CW-type PWWP domain protein 1 isoform X3

    UniProtKB/TrEMBL
    F1LT90, M0RC55
    Related
    ENSRNOP00000062266.4
    Conserved Domains (2) summary
    pfam07496
    Location:238 → 283
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:295 → 397
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  2. XM_063271778.1 → XP_063127848.1  zinc finger CW-type PWWP domain protein 1 isoform X6

  3. XM_039090047.2 → XP_038945975.1  zinc finger CW-type PWWP domain protein 1 isoform X4

    UniProtKB/TrEMBL
    M0RC55
    Conserved Domains (2) summary
    pfam07496
    Location:237 → 282
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:294 → 396
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  4. XM_063271776.1 → XP_063127846.1  zinc finger CW-type PWWP domain protein 1 isoform X2

  5. XM_063271777.1 → XP_063127847.1  zinc finger CW-type PWWP domain protein 1 isoform X5

  6. XM_063271779.1 → XP_063127849.1  zinc finger CW-type PWWP domain protein 1 isoform X7

  7. XM_063271775.1 → XP_063127845.1  zinc finger CW-type PWWP domain protein 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.