Castor2 cytosolic arginine sensor for mTORC1 subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Castor2provided by RGD
Official Full Name: cytosolic arginine sensor for mTORC1 subunit 2provided by RGD
Primary source: RGD:1304672
See related: Ensembl:ENSRNOG00000067286 AllianceGenome:RGD:1304672
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gats; Gatsl2
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in cellular response to L-arginine and negative regulation of TORC1 signaling. Predicted to be part of GATOR2 complex. Predicted to be active in cytosol. Orthologous to human CASTOR2 (cytosolic arginine sensor for mTORC1 subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 55.3), Brain (RPKM 55.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (28213927..28256593, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (22577504..22620182, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (25595800..25638806, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables arginine binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to L-arginine	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GATOR2 complex	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytosolic arginine sensor for mTORC1 subunit 2

Names: GATS protein-like 2; GATS-like protein 2; opposite strand transcription unit to Stag3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100561.2 → NP_001094031.1 cytosolic arginine sensor for mTORC1 subunit 2

See identical proteins and their annotated locations for NP_001094031.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6J0K8, G3V665

Related

ENSRNOP00000095312.1, ENSRNOT00000110618.1

Conserved Domains (2) summary

pfam13840
Location:260 → 322

ACT_7; ACT domain

pfam18700
Location:9 → 69

Castor1_N; Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain