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Kntc1 kinetochore associated 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304477, updated on 3-Apr-2024

Summary

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Symbol
Kntc1provided by RGD
Full Name
kinetochore associated 1provided by RGD
Primary source
RGD:1307905
See related
Ensembl:ENSRNOG00000033658 AllianceGenome:RGD:1307905
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore involved in kinetochore assembly. Predicted to be located in cytoskeleton; cytosol; and plasma membrane. Predicted to be part of RZZ complex. Predicted to be active in cytoplasm and kinetochore microtubule. Orthologous to human KNTC1 (kinetochore associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 82.4), Spleen (RPKM 52.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kntc1 in Genome Data Viewer
Location:
12q15-q16
Exon count:
65
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38429925..38500564, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32769020..32839617, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (38200463..38274162, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene hydroxycarboxylic acid receptor 1 Neighboring gene hydroxycarboxylic acid receptor 2 Neighboring gene arginine and serine rich coiled-coil 2 Neighboring gene zinc finger CCHC-type containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores. Chan GK, et al. Nat Cell Biol, 2000 Dec. PMID 11146660
  2. Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. Civril F, et al. Structure, 2010 May 12. PMID 20462495
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to kinetochore involved in kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RZZ complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RZZ complex ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinetochore-associated protein 1
Names
kinetochore-associated protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107140.1 → NP_001100610.1  kinetochore-associated protein 1

    See identical proteins and their annotated locations for NP_001100610.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    A6J131, D3ZVJ3
    Related
    ENSRNOP00000063431.2, ENSRNOT00000063990.4
    Conserved Domains (1) summary
    pfam10493
    Location:1427 → 1970
    Rod_C; Rough deal protein C-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    38429925..38500564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769228.4 → XP_008767450.1  kinetochore-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008767450.1

    UniProtKB/TrEMBL
    A0A8I6G9X6
    Related
    ENSRNOP00000084132.1
    Conserved Domains (1) summary
    pfam10493
    Location:1582 → 2125
    Rod_C; Rough deal protein C-terminal region

  2. XM_063271315.1 → XP_063127385.1  kinetochore-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G9X6

  3. XM_039089456.2 → XP_038945384.1  kinetochore-associated protein 1 isoform X2

    Conserved Domains (1) summary
    pfam10493
    Location:1430 → 1974
    Rod_C; Rough deal protein C-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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