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Cfap251 cilia and flagella associated protein 251 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304498, updated on 5-Mar-2024

Summary

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Official Symbol
Cfap251provided by RGD
Official Full Name
cilia and flagella associated protein 251provided by RGD
Primary source
RGD:1564948
See related
AllianceGenome:RGD:1564948
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wdr66; RGD1564948
Summary
Predicted to be involved in flagellated sperm motility. Predicted to be located in sperm flagellum. Human ortholog(s) of this gene implicated in spermatogenic failure 33. Orthologous to human CFAP251 (cilia and flagella associated protein 251). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 57.1), Brain (RPKM 36.6) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q16
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38923154..38997881, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (33261622..33337028, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (38708915..38781598, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene MLX interacting protein Neighboring gene U4 spliceosomal RNA Neighboring gene BAF chromatin remodeling complex subunit BCL7A Neighboring gene uncharacterized LOC120095967 Neighboring gene uncharacterized LOC120095968 Neighboring gene proteasome 26S subunit, non-ATPase 9 Neighboring gene uncharacterized LOC102547495 Neighboring gene 4-hydroxyphenylpyruvate dioxygenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Homozygous Ancestral SVA-Insertion-Mediated Deletion in WDR66 Induces Multiple Morphological Abnormalities of the Sperm Flagellum and Male Infertility. Kherraf ZE, et al. Am J Hum Genet, 2018 Sep 6. PMID 30122540, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 66; cilia- and flagella-associated protein 251
Names
WD repeat domain 66

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    38923154..38997881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769275.3 → XP_008767497.2  cilia- and flagella-associated protein 251

    Conserved Domains (4) summary
    COG2319
    Location:301 → 734
    WD40; WD40 repeat [General function prediction only]
    COG5126
    Location:1026 → 1134
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    sd00039
    Location:591 → 650
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:653 → 967
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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