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Rnft2 ring finger protein, transmembrane 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304521, updated on 13-Apr-2024

Summary

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Official Symbol
Rnft2provided by RGD
Official Full Name
ring finger protein, transmembrane 2provided by RGD
Primary source
RGD:1560195
See related
Ensembl:ENSRNOG00000001124 AllianceGenome:RGD:1560195
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tmem118; RGD1560195
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of ERAD pathway and protein ubiquitination. Predicted to be integral component of membrane. Orthologous to human RNFT2 (ring finger protein, transmembrane 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 96.3) and Testes (RPKM 6.9) See more
Orthologs
human mouse all
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Genomic context

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Location:
12q16
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (43990113..44048215)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (38329217..38387303)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (43940929..44008685)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene SREBF pathway regulator in golgi 1 Neighboring gene uncharacterized LOC102553921 Neighboring gene harakiri, BCL2 interacting protein Neighboring gene U6 spliceosomal RNA Neighboring gene F-box and WD repeat domain containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of ERAD pathway IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNFT2
Names
RING finger and transmembrane domain-containing protein 2
transmembrane protein 118

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107144.2 → NP_001100614.1  E3 ubiquitin-protein ligase RNFT2

    See identical proteins and their annotated locations for NP_001100614.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J1L9, A6J1M0, D3ZTN5
    Related
    ENSRNOP00000001486.7, ENSRNOT00000001486.8
    Conserved Domains (2) summary
    cd00162
    Location:385 → 422
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl17238
    Location:384 → 423
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    43990113..44048215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089494.2 → XP_038945422.1  E3 ubiquitin-protein ligase RNFT2 isoform X2

  2. XM_063271344.1 → XP_063127414.1  E3 ubiquitin-protein ligase RNFT2 isoform X1

    UniProtKB/TrEMBL
    A6J1M0, D3ZTN5

  3. XM_039089493.2 → XP_038945421.1  E3 ubiquitin-protein ligase RNFT2 isoform X1

    UniProtKB/TrEMBL
    A6J1L9, A6J1M0, D3ZTN5
    Conserved Domains (2) summary
    cd00162
    Location:385 → 422
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl17238
    Location:384 → 423
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  4. XM_039089492.2 → XP_038945420.1  E3 ubiquitin-protein ligase RNFT2 isoform X1

    UniProtKB/TrEMBL
    A6J1L9, A6J1M0, D3ZTN5
    Conserved Domains (2) summary
    cd00162
    Location:385 → 422
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl17238
    Location:384 → 423
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version

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