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Clasp1 cytoplasmic linker associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304740, updated on 13-Apr-2024

Summary

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Official Symbol
Clasp1provided by RGD
Official Full Name
cytoplasmic linker associated protein 1provided by RGD
Primary source
RGD:1310970
See related
Ensembl:ENSRNOG00000002376 AllianceGenome:RGD:1310970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dystroglycan binding activity; kinetochore binding activity; and microtubule plus-end binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; negative regulation of cytoskeleton organization; and positive regulation of extracellular matrix organization. Predicted to act upstream of or within cell division; establishment of spindle orientation; and negative regulation of microtubule depolymerization. Located in cytoplasm and kinetochore. Orthologous to human CLASP1 (cytoplasmic linker associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 196.2), Muscle (RPKM 179.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Clasp1 in Genome Data Viewer
Location:
13q11
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (32046362..32267954)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (29493554..29715151)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (34365038..34584651)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene nucleolar protein interacting with the FHA domain of MKI67 Neighboring gene 60S ribosomal protein L7-like Neighboring gene heat shock protein 90 alpha family class A member 1, pseudogene 5 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U4atac minor spliceosomal RNA Neighboring gene uncharacterized LOC134481480 Neighboring gene transcription factor CP2-like 1 Neighboring gene uncharacterized LOC120096197

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population. Hallberg P, et al. Pharmacogenomics, 2017 Feb. PMID 28084903
  2. Critical roles of Astrin in the mitosis of immature rat Sertoli cells. Tochigi Y, et al. Biochem Biophys Res Commun, 2017 May 13. PMID 28351621
  3. Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics. Maiato H, et al. Cell, 2003 Jun 27. PMID 12837247
  4. Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner. Efimova N, et al. J Cell Sci, 2014 Dec 15. PMID 25344256, Free PMC Article
  5. Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. Pereira AL, et al. Mol Biol Cell, 2006 Oct. PMID 16914514, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dystroglycan binding ISO
Inferred from Sequence Orthology
more info
  
enables kinetochore binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinetochore binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in astral microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of mitotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of mitotic spindle localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of spindle orientation ISO
Inferred from Sequence Orthology
more info
  
involved_in exit from mitosis ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule anchoring ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule organizing center organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gastrulation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle targeting ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in basal cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basal cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosomal corona ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cortical microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CLIP-associating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427589.1 → NP_001414518.1  CLIP-associating protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    32046362..32267954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272238.1 → XP_063128308.1  CLIP-associating protein 1 isoform X1

  2. XM_063272254.1 → XP_063128324.1  CLIP-associating protein 1 isoform X16

  3. XM_063272256.1 → XP_063128326.1  CLIP-associating protein 1 isoform X18

  4. XM_063272274.1 → XP_063128344.1  CLIP-associating protein 1 isoform X39

  5. XM_063272239.1 → XP_063128309.1  CLIP-associating protein 1 isoform X2

  6. XM_063272240.1 → XP_063128310.1  CLIP-associating protein 1 isoform X3

  7. XM_063272257.1 → XP_063128327.1  CLIP-associating protein 1 isoform X20

  8. XM_063272248.1 → XP_063128318.1  CLIP-associating protein 1 isoform X11

  9. XM_039091269.2 → XP_038947197.1  CLIP-associating protein 1 isoform X22

    UniProtKB/TrEMBL
    A0A1B0GWM1
    Related
    ENSRNOP00000075946.2
    Conserved Domains (3) summary
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:324 → 537
    CLASP_N; CLASP N terminal

  10. XM_063272251.1 → XP_063128321.1  CLIP-associating protein 1 isoform X13

  11. XM_063272259.1 → XP_063128329.1  CLIP-associating protein 1 isoform X24

    UniProtKB/TrEMBL
    F1LNR1

  12. XM_039091273.2 → XP_038947201.1  CLIP-associating protein 1 isoform X23

    UniProtKB/TrEMBL
    A0A8I5ZL32
    Conserved Domains (3) summary
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:324 → 537
    CLASP_N; CLASP N terminal

  13. XM_063272241.1 → XP_063128311.1  CLIP-associating protein 1 isoform X4

  14. XM_063272260.1 → XP_063128330.1  CLIP-associating protein 1 isoform X25

  15. XM_063272264.1 → XP_063128334.1  CLIP-associating protein 1 isoform X29

  16. XM_063272242.1 → XP_063128312.1  CLIP-associating protein 1 isoform X5

  17. XM_063272261.1 → XP_063128331.1  CLIP-associating protein 1 isoform X26

  18. XM_063272244.1 → XP_063128314.1  CLIP-associating protein 1 isoform X7

  19. XM_063272262.1 → XP_063128332.1  CLIP-associating protein 1 isoform X27

  20. XM_039091263.2 → XP_038947191.1  CLIP-associating protein 1 isoform X19

    UniProtKB/TrEMBL
    F1LNR0
    Conserved Domains (3) summary
    sd00044
    Location:93 → 120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:324 → 537
    CLASP_N; CLASP N terminal

  21. XM_063272245.1 → XP_063128315.1  CLIP-associating protein 1 isoform X8

  22. XM_063272263.1 → XP_063128333.1  CLIP-associating protein 1 isoform X28

  23. XM_063272267.1 → XP_063128337.1  CLIP-associating protein 1 isoform X32

  24. XM_063272247.1 → XP_063128317.1  CLIP-associating protein 1 isoform X10

  25. XM_063272269.1 → XP_063128339.1  CLIP-associating protein 1 isoform X34

  26. XM_063272249.1 → XP_063128319.1  CLIP-associating protein 1 isoform X12

  27. XM_063272265.1 → XP_063128335.1  CLIP-associating protein 1 isoform X30

  28. XM_063272270.1 → XP_063128340.1  CLIP-associating protein 1 isoform X35

  29. XM_063272252.1 → XP_063128322.1  CLIP-associating protein 1 isoform X14

  30. XM_063272266.1 → XP_063128336.1  CLIP-associating protein 1 isoform X31

  31. XM_063272243.1 → XP_063128313.1  CLIP-associating protein 1 isoform X6

  32. XM_063272273.1 → XP_063128343.1  CLIP-associating protein 1 isoform X38

  33. XM_063272246.1 → XP_063128316.1  CLIP-associating protein 1 isoform X9

  34. XM_063272268.1 → XP_063128338.1  CLIP-associating protein 1 isoform X33

  35. XM_063272253.1 → XP_063128323.1  CLIP-associating protein 1 isoform X15

  36. XM_063272271.1 → XP_063128341.1  CLIP-associating protein 1 isoform X36

  37. XM_063272255.1 → XP_063128325.1  CLIP-associating protein 1 isoform X17

  38. XM_063272272.1 → XP_063128342.1  CLIP-associating protein 1 isoform X37

  39. XM_063272258.1 → XP_063128328.1  CLIP-associating protein 1 isoform X21

Nucleotide Protein Strain
Heading Accession and Version

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