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Slc26a9 solute carrier family 26 member 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304784, updated on 11-Apr-2024

Summary

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Official Symbol
Slc26a9provided by RGD
Official Full Name
solute carrier family 26 member 9provided by RGD
Primary source
RGD:1310441
See related
Ensembl:ENSRNOG00000029514 AllianceGenome:RGD:1310441
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATPase binding activity and anion transmembrane transporter activity. Predicted to be involved in positive regulation of gene expression. Predicted to act upstream of or within bicarbonate transport; chloride transport; and regulation of pH. Predicted to be located in apical plasma membrane and cell surface. Predicted to be integral component of plasma membrane. Orthologous to human SLC26A9 (solute carrier family 26 member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 40.1), Kidney (RPKM 10.8) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc26a9 in Genome Data Viewer
Location:
13q13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (45730022..45757662)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43177806..43205450)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (48512415..48539467)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene Rab7b, member RAS oncogene family Neighboring gene uncharacterized LOC134481493 Neighboring gene uncharacterized LOC103691878 Neighboring gene peptidase M20 domain containing 1 Neighboring gene solute carrier family 41 member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional analysis of nonsynonymous single nucleotide polymorphisms in human SLC26A9. Chen AP, et al. Hum Mutat, 2012 Aug. PMID 22544634, Free PMC Article
  2. Characterization of SLC26A9, facilitation of Cl(-) transport by bicarbonate. Loriol C, et al. Cell Physiol Biochem, 2008. PMID 18769029
  3. Identification of SLC26A transporters involved in the Cl⁻/HCO₃⁻ exchange in proximal tubular cells from WKY and SHR. Simão S, et al. Life Sci, 2013 Oct 6. PMID 23933130
  4. SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia. Bertrand CA, et al. J Gen Physiol, 2009 Apr. PMID 19289574, Free PMC Article
  5. SLC26A9 stimulates CFTR expression and function in human bronchial cell lines. Avella M, et al. J Cell Physiol, 2011 Jan. PMID 20658517

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of slc26a4, slc26a6 and slc26a9 is increased in proximal tubule epithelial cells from spontaneously hypertensive rats compared with WKY control rats.
    Title: Identification of SLC26A transporters involved in the Cl⁻/HCO₃⁻ exchange in proximal tubular cells from WKY and SHR.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bicarbonate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride:bicarbonate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables solute:inorganic anion antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bicarbonate transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chloride transport ISO
Inferred from Sequence Orthology
more info
  
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in oxalate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of pH ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 26 member 9
Names
solute carrier family 26 (anion exchanger), member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107172.1 → NP_001100642.1  solute carrier family 26 member 9

    See identical proteins and their annotated locations for NP_001100642.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473958
    UniProtKB/TrEMBL
    A6IC30, D3ZV32
    Related
    ENSRNOP00000009742.4, ENSRNOT00000009742.5
    Conserved Domains (1) summary
    TIGR00815
    Location:57 → 733
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    45730022..45757662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090696.1 → XP_038946624.1  solute carrier family 26 member 9 isoform X3

    Conserved Domains (1) summary
    pfam00916
    Location:74 → 468
    Sulfate_transp; Sulfate permease family

  2. XM_017598789.3 → XP_017454278.2  solute carrier family 26 member 9 isoform X1

    UniProtKB/TrEMBL
    A6IC30, D3ZV32
    Conserved Domains (1) summary
    TIGR00815
    Location:57 → 733
    sulP; high affinity sulphate transporter 1

  3. XM_039090695.1 → XP_038946623.1  solute carrier family 26 member 9 isoform X2

    Conserved Domains (1) summary
    TIGR00815
    Location:8 → 569
    sulP; high affinity sulphate transporter 1
Nucleotide Protein Strain
Heading Accession and Version

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