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Slc45a3 solute carrier family 45, member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304785, updated on 12-May-2024

Summary

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Official Symbol
Slc45a3provided by RGD
Official Full Name
solute carrier family 45, member 3provided by RGD
Primary source
RGD:1309764
See related
Ensembl:ENSRNOG00000007591 AllianceGenome:RGD:1309764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309764
Summary
Predicted to enable sucrose:proton symporter activity. Predicted to be involved in positive regulation of fatty acid biosynthetic process; positive regulation of glucose metabolic process; and regulation of oligodendrocyte differentiation. Predicted to act upstream of or within sucrose transport. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human SLC45A3 (solute carrier family 45 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 49.1), Spleen (RPKM 47.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (45959467..45979763)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43407293..43427588)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (48745855..48766283)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene RAN, member RAS oncogene family, pseudogene 4 Neighboring gene uncharacterized LOC134481494 Neighboring gene ETS transcription factor ELK4 Neighboring gene major facilitator superfamily domain containing 4A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. miR-32 and its target SLC45A3 regulate the lipid metabolism of oligodendrocytes and myelin. Shin D, et al. Neuroscience, 2012 Jun 28. PMID 22521588, Free PMC Article
  2. Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae. Bartölke R, et al. Biochem J, 2014 Dec 1. PMID 25164149
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables sucrose:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sucrose:proton symporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sucrose transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 45 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135868.2 → NP_001129340.1  solute carrier family 45 member 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    D3ZPP5
    Related
    ENSRNOP00000010242.5, ENSRNOT00000010242.6
    Conserved Domains (1) summary
    cd17313
    Location:18 → 537
    MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

  2. NM_001430073.1 → NP_001417002.1  solute carrier family 45 member 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  3. NM_001430074.1 → NP_001417003.1  solute carrier family 45 member 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  4. NM_001430075.1 → NP_001417004.1  solute carrier family 45 member 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    45959467..45979763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249765.5 → XP_006249827.1  solute carrier family 45 member 3 isoform X1

    UniProtKB/TrEMBL
    A6IC37, D3ZPP5
    Conserved Domains (1) summary
    cd17313
    Location:29 → 548
    MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

  2. XM_006249767.4 → XP_006249829.1  solute carrier family 45 member 3 isoform X1

    UniProtKB/TrEMBL
    A6IC37, D3ZPP5
    Conserved Domains (1) summary
    cd17313
    Location:29 → 548
    MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

  3. XM_006249766.4 → XP_006249828.1  solute carrier family 45 member 3 isoform X1

    UniProtKB/TrEMBL
    A6IC37, D3ZPP5
    Conserved Domains (1) summary
    cd17313
    Location:29 → 548
    MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters
Nucleotide Protein Strain
Heading Accession and Version

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