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Npl N-acetylneuraminate pyruvate lyase [ Rattus norvegicus (Norway rat) ]

Gene ID: 304860, updated on 2-May-2024

Summary

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Official Symbol
Nplprovided by RGD
Official Full Name
N-acetylneuraminate pyruvate lyaseprovided by RGD
Primary source
RGD:1549702
See related
Ensembl:ENSRNOG00000002775 AllianceGenome:RGD:1549702
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N-acetylneuraminate lyase activity and identical protein binding activity. Predicted to be involved in N-acetylneuraminate catabolic process. Predicted to be located in cytoplasm. Orthologous to human NPL (N-acetylneuraminate pyruvate lyase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 93.0), Spleen (RPKM 66.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Npl in Genome Data Viewer
Location:
13q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (68205602..68247940, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (65655099..65697464, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (70938073..70981179, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene SHC binding and spindle associated 1 like Neighboring gene DExH-box helicase 9 Neighboring gene S100 calcium binding protein A11, pseudogene 1 Neighboring gene regulator of G-protein signaling 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The sialate-pyruvate lyase from pig kidney. Elucidation of the primary structure and expression of recombinant enzyme activity. Traving C, et al. Eur J Biochem, 2001 Dec. PMID 11737202
  2. Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. Bergfeld AK, et al. J Biol Chem, 2012 Aug 17. PMID 22692205, Free PMC Article
  3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetylneuraminate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylneuraminate lyase activity ISO
Inferred from Sequence Orthology
more info
  
enables N-acetylneuraminate lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxo-acid-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acetylneuraminate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acetylneuraminate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylneuraminate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-acetylneuraminate catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylneuraminate lyase
Names
N-acetylneuraminic acid aldolase
NALase
sialate lyase
sialate-pyruvate lyase
sialic acid aldolase
sialic acid lyase
NP_001014006.1
XP_006250059.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013984.1 → NP_001014006.1  N-acetylneuraminate lyase

    See identical proteins and their annotated locations for NP_001014006.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082004
    UniProtKB/Swiss-Prot
    Q66H59
    UniProtKB/TrEMBL
    A0A8L2Q119
    Related
    ENSRNOP00000097337.1, ENSRNOT00000109291.1
    Conserved Domains (1) summary
    cl21457
    Location:8 → 306
    TIM; TIM-like beta/alpha barrel domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    68205602..68247940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249997.5 → XP_006250059.1  N-acetylneuraminate lyase isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q119
    Conserved Domains (1) summary
    cl21457
    Location:8 → 275
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H59.1 GenPept UniProtKB/Swiss-Prot:Q66H59

Gene LinkOut

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