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Igsf8 immunoglobulin superfamily, member 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304979, updated on 2-May-2024

Summary

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Official Symbol
Igsf8provided by RGD
Official Full Name
immunoglobulin superfamily, member 8provided by RGD
Primary source
RGD:1311500
See related
Ensembl:ENSRNOG00000007604 AllianceGenome:RGD:1311500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to act upstream of or within regulation of cell motility. Predicted to be located in axon; intracellular membrane-bounded organelle; and synapse. Predicted to be integral component of membrane. Orthologous to human IGSF8 (immunoglobulin superfamily member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 154.4), Adrenal (RPKM 50.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (87282015..87314018)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (84770348..84781534)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (90692590..90703262)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene calsequestrin 1 Neighboring gene ATPase Na+/K+ transporting subunit alpha 4 Neighboring gene ATPase Na+/K+ transporting subunit alpha 2 Neighboring gene uncharacterized LOC134481592 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 9 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins. Clark KL, et al. J Immunol, 2001 Nov 1. PMID 11673522
  2. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. Stipp CS, et al. J Biol Chem, 2001 Nov 2. PMID 11504738
  3. IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses. Ray A, et al. Mol Cell Neurosci, 2012 Jul. PMID 22687584, Free PMC Article
  4. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
  5. Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. Werner HB, et al. J Neurosci, 2007 Jul 18. PMID 17634366, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105805

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in hippocampal mossy fiber to CA3 synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
immunoglobulin superfamily member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014787.2 → NP_001014787.1  immunoglobulin superfamily member 8 precursor

    See identical proteins and their annotated locations for NP_001014787.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A140TAA1
    Conserved Domains (2) summary
    cd00096
    Location:41 → 49
    Ig; Ig strand B [structural motif]
    cl11960
    Location:40 → 147
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    87282015..87314018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272372.1 → XP_063128442.1  immunoglobulin superfamily member 8 isoform X3

  2. XM_017598830.3 → XP_017454319.2  immunoglobulin superfamily member 8 isoform X1

    UniProtKB/TrEMBL
    A0A140TAA1, A0A8I6ANQ3
    Related
    ENSRNOP00000095607.1
    Conserved Domains (2) summary
    cd00096
    Location:91 → 99
    Ig; Ig strand B [structural motif]
    cl11960
    Location:90 → 197
    Ig; Immunoglobulin domain

  3. XM_006250289.5 → XP_006250351.1  immunoglobulin superfamily member 8 isoform X4

    UniProtKB/TrEMBL
    A0A140TAA1
    Related
    ENSRNOP00000076903.1
    Conserved Domains (1) summary
    cl11960
    Location:385 → 493
    Ig; Immunoglobulin domain

  4. XM_039090796.2 → XP_038946724.1  immunoglobulin superfamily member 8 isoform X2

    UniProtKB/TrEMBL
    A0A140TAA1
    Conserved Domains (2) summary
    cd00096
    Location:41 → 49
    Ig; Ig strand B [structural motif]
    cl11960
    Location:40 → 147
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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