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Zfp281 zinc finger protein 281 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305083, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp281provided by RGD
Official Full Name
zinc finger protein 281provided by RGD
Primary source
RGD:1305139
See related
Ensembl:ENSRNOG00000058643 AllianceGenome:RGD:1305139
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic body morphogenesis; regulation of gene expression; and stem cell differentiation. Predicted to be located in nucleoplasm. Orthologous to human ZNF281 (zinc finger protein 281). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 159.5), Adrenal (RPKM 117.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (50647750..50655912)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (48096103..48104265)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (53531080..53534399)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide B2, pseudogene 1 Neighboring gene transfer RNA proline (anticodon AGG) 34 Neighboring gene uncharacterized LOC102547588 Neighboring gene uncharacterized LOC120096258 Neighboring gene uncharacterized LOC134481566

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression. Law DJ, et al. Biochem Biophys Res Commun, 1999 Aug 19. PMID 10448078
  2. Identification of human GC-box-binding zinc finger protein, a new Krüppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence. Lisowsky T, et al. FEBS Lett, 1999 Jun 25. PMID 10405178
  3. Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Fidalgo M, et al. Stem Cells, 2011 Nov. PMID 21915945, Free PMC Article
  4. Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming. Fidalgo M, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22988117, Free PMC Article
  5. ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1. Zhang X, et al. Nucleic Acids Res, 2003 Jun 1. PMID 12771217, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in embryonic body morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger protein 281

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012030.1 → NP_001012030.1  zinc finger protein 281

    See identical proteins and their annotated locations for NP_001012030.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083844
    UniProtKB/TrEMBL
    A0A0G2K3M5, A6ICJ2, Q5XI48
    Conserved Domains (3) summary
    sd00017
    Location:256 → 276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:324 → 349
    zf-H2C2_2; Zinc-finger double domain
    pfam13894
    Location:254 → 276
    zf-C2H2_4; C2H2-type zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    50647750..50655912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090831.1 → XP_038946759.1  zinc finger protein 281 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K3M5, A6ICJ2, Q5XI48
    Related
    ENSRNOP00000072700.2, ENSRNOT00000088133.2
    Conserved Domains (3) summary
    sd00017
    Location:256 → 276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:324 → 349
    zf-H2C2_2; Zinc-finger double domain
    pfam13894
    Location:254 → 276
    zf-C2H2_4; C2H2-type zinc finger
Nucleotide Protein Strain
Heading Accession and Version

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