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Pds5a PDS5 cohesin associated factor A [ Rattus norvegicus (Norway rat) ]

Gene ID: 305343, updated on 3-Apr-2024

Summary

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Official Symbol
Pds5aprovided by RGD
Official Full Name
PDS5 cohesin associated factor Aprovided by RGD
Primary source
RGD:1307094
See related
Ensembl:ENSRNOG00000002541 AllianceGenome:RGD:1307094
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Scc-112; RGD1307094
Summary
Predicted to be involved in DNA repair; mitotic sister chromatid cohesion; and negative regulation of DNA replication. Predicted to act upstream of or within several processes, including animal organ development; neuroblast migration; and roof of mouth development. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in chromatin and nucleus. Orthologous to human PDS5A (PDS5 cohesin associated factor A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 354.9), Spleen (RPKM 270.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p11
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (42905734..43004740)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42551653..42651074)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44185445..44282308)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene HAUS augmin-like complex, subunit 8, pseudogene 3 Neighboring gene NEDD4 binding protein 2 Neighboring gene ras homolog family member H Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L14 like 2 Neighboring gene ubiquitin-conjugating enzyme E2K Neighboring gene ribosomal protein lateral stalk subunit P2 like 3 Neighboring gene small integral membrane protein 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors. Hagemann C, et al. Int J Mol Med, 2011 Jan. PMID 21069257
  2. Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. Zhang B, et al. PLoS One, 2009. PMID 19412548, Free PMC Article
  3. Cohesin acetylation speeds the replication fork. Terret ME, et al. Nature, 2009 Nov 12. PMID 19907496, Free PMC Article
  4. Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Watrin E, et al. Curr Biol, 2006 May 9. PMID 16682347
  5. Sororin mediates sister chromatid cohesion by antagonizing Wapl. Nishiyama T, et al. Cell, 2010 Nov 24. PMID 21111234

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells.
    Title: The cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lens development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metanephros development ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neuroblast migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IEA
Inferred from Electronic Annotation
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sister chromatid cohesion protein PDS5 homolog A
Names
PDS5, regulator of cohesion maintenance, homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083624.1 → NP_001077093.1  sister chromatid cohesion protein PDS5 homolog A

    See identical proteins and their annotated locations for NP_001077093.1

    Status: PROVISIONAL

    Source sequence(s)
    EF460313
    UniProtKB/Swiss-Prot
    A4L9P7
    Conserved Domains (2) summary
    sd00044
    Location:282 → 312
    HEAT; HEAT repeat [structural motif]
    cd19953
    Location:40 → 670
    PDS5; Sister chromatid cohesion protein PDS5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    42905734..43004740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091918.2 → XP_038947846.1  sister chromatid cohesion protein PDS5 homolog A isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q0A3, A6JDD2
    Conserved Domains (2) summary
    sd00044
    Location:282 → 312
    HEAT; HEAT repeat [structural motif]
    cd19953
    Location:40 → 670
    PDS5; Sister chromatid cohesion protein PDS5

  2. XM_063273132.1 → XP_063129202.1  sister chromatid cohesion protein PDS5 homolog A isoform X3

  3. XM_063273131.1 → XP_063129201.1  sister chromatid cohesion protein PDS5 homolog A isoform X2

    UniProtKB/Swiss-Prot
    A4L9P7

  4. XM_063273133.1 → XP_063129203.1  sister chromatid cohesion protein PDS5 homolog A isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4L9P7.1 GenPept UniProtKB/Swiss-Prot:A4L9P7

Gene LinkOut

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