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Lias lipoic acid synthetase [ Rattus norvegicus (Norway rat) ]

Gene ID: 305348, updated on 5-Mar-2024

Summary

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Official Symbol
Liasprovided by RGD
Official Full Name
lipoic acid synthetaseprovided by RGD
Primary source
RGD:1307270
See related
Ensembl:ENSRNOG00000002759 AllianceGenome:RGD:1307270
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable lipoate synthase activity. Predicted to be involved in lipoate biosynthetic process. Predicted to act upstream of or within several processes, including neural tube closure; response to lipopolysaccharide; and response to oxidative stress. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 190.8), Kidney (RPKM 161.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lias in Genome Data Viewer
Location:
14p11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43230369..43247469, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42876699..42893824, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44507217..44524287, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P2 like 3 Neighboring gene small integral membrane protein 14 Neighboring gene UDP-glucose 6-dehydrogenase Neighboring gene ribosomal protein L9 Neighboring gene uncharacterized LOC134481848 Neighboring gene klotho beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mice with heterozygous deficiency of lipoic acid synthase have an increased sensitivity to lipopolysaccharide-induced tissue injury. Yi X, et al. J Leukoc Biol, 2009 Jan. PMID 18845616, Free PMC Article
  2. Do mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in mitochondria. Morikawa T, et al. FEBS Lett, 2001 Jun 1. PMID 11389890
  3. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. García-García MJ, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15755804, Free PMC Article
  4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables lipoate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipoate synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in lipoate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipoate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lipoyl synthase, mitochondrial
Names
LS
lip-syn
lipoate synthase
lipoic acid synthase
NP_001012037.1
XP_038947848.1
XP_063129204.1
XP_063129205.1
XP_063129206.1
XP_063129207.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012037.1 → NP_001012037.1  lipoyl synthase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001012037.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083708
    UniProtKB/Swiss-Prot
    Q5XIH4
    Related
    ENSRNOP00000003779.3, ENSRNOT00000003779.5
    Conserved Domains (1) summary
    PLN02428
    Location:41 → 369
    PLN02428; lipoic acid synthase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    43230369..43247469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273137.1 → XP_063129207.1  lipoyl synthase, mitochondrial isoform X5

  2. XM_039091920.2 → XP_038947848.1  lipoyl synthase, mitochondrial isoform X3

    Conserved Domains (1) summary
    PLN02428
    Location:41 → 326
    PLN02428; lipoic acid synthase

  3. XM_063273135.1 → XP_063129205.1  lipoyl synthase, mitochondrial isoform X2

  4. XM_063273134.1 → XP_063129204.1  lipoyl synthase, mitochondrial isoform X1

  5. XM_063273136.1 → XP_063129206.1  lipoyl synthase, mitochondrial isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIH4.1 GenPept UniProtKB/Swiss-Prot:Q5XIH4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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