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Eif4enif1 eukaryotic translation initiation factor 4E nuclear import factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305468, updated on 5-Mar-2024

Summary

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Official Symbol
Eif4enif1provided by RGD
Official Full Name
eukaryotic translation initiation factor 4E nuclear import factor 1provided by RGD
Primary source
RGD:1560908
See related
Ensembl:ENSRNOG00000018475 AllianceGenome:RGD:1560908
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560908
Summary
Predicted to enable kinase binding activity; mRNA binding activity; and nuclear export signal receptor activity. Predicted to be involved in several processes, including P-body assembly; regulation of mRNA catabolic process; and regulation of translation. Predicted to act upstream of or within negative regulation of neuron differentiation and stem cell population maintenance. Predicted to be located in P-body; cytosol; and intracellular membrane-bounded organelle. Predicted to be active in cytoplasm and nucleus. Orthologous to human EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 98.5), Spleen (RPKM 79.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14q21
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (82280566..82328559)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78056115..78099846)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (83412843..83455694)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene phosphatidylserine decarboxylase Neighboring gene SFI1 centrin binding protein Neighboring gene uncharacterized LOC134481863 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 1 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene U7 small nuclear RNA Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene LIM domain kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. Dostie J, et al. EMBO J, 2000 Jun 15. PMID 10856257, Free PMC Article
  2. Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation. Villaescusa JC, et al. Gene, 2006 Feb 15. PMID 16343815
  3. An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Yang G, et al. Neuron, 2014 Nov 19. PMID 25456498
  4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear export signal receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in P-body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear export IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 4E transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107230.1 → NP_001100700.1  eukaryotic translation initiation factor 4E transporter

    See identical proteins and their annotated locations for NP_001100700.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473963
    UniProtKB/TrEMBL
    A0A8I6AC32, A6IK92, A6IK93, D4ACF1
    Related
    ENSRNOP00000024993.5, ENSRNOT00000024993.6
    Conserved Domains (1) summary
    pfam10477
    Location:30 → 711
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    82280566..82328559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251291.5 → XP_006251353.1  eukaryotic translation initiation factor 4E transporter isoform X2

    See identical proteins and their annotated locations for XP_006251353.1

    UniProtKB/TrEMBL
    A0A8I6AC32, A6IK92, A6IK93, D4ACF1
    Conserved Domains (1) summary
    pfam10477
    Location:30 → 711
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

  2. XM_006251290.5 → XP_006251352.1  eukaryotic translation initiation factor 4E transporter isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9M0, A0A8I6AC32, A6IK93
    Related
    ENSRNOP00000089338.1
    Conserved Domains (1) summary
    pfam10477
    Location:49 → 730
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
Nucleotide Protein Strain
Heading Accession and Version

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