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Dusp18 dual specificity phosphatase 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305477, updated on 13-Apr-2024

Summary

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Official Symbol
Dusp18provided by RGD
Official Full Name
dual specificity phosphatase 18provided by RGD
Primary source
RGD:1306929
See related
Ensembl:ENSRNOG00000024945 AllianceGenome:RGD:1306929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in peptidyl-threonine dephosphorylation and peptidyl-tyrosine dephosphorylation. Located in mitochondrial intermembrane space. Is extrinsic component of mitochondrial inner membrane. Orthologous to human DUSP18 (dual specificity phosphatase 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 49.0), Testes (RPKM 33.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dusp18 in Genome Data Viewer
Location:
14q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (83013850..83035168)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78790183..78811576)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (84150484..84169645)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transcription initiation factor IIA subunit 2-like Neighboring gene similar to human chromosome 5 open reading frame 52 Neighboring gene solute carrier family 35, member E4 Neighboring gene transcobalamin 2 Neighboring gene pescadillo ribosomal biogenesis factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain. Wu Q, et al. Biochim Biophys Acta, 2003 Feb 20. PMID 12591617
  2. Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. Hood KL, et al. Biochem Biophys Res Commun, 2002 Nov 8. PMID 12408986
  3. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. Rardin MJ, et al. J Biol Chem, 2008 May 30. PMID 18385140, Free PMC Article
  4. The family-wide structure and function of human dual-specificity protein phosphatases. Jeong DG, et al. Acta Crystallogr D Biol Crystallogr, 2014 Feb. PMID 24531476
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane
    Title: Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 18
NP_001013146.2
XP_006251361.1
XP_063129275.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013128.2 → NP_001013146.2  dual specificity protein phosphatase 18

    See identical proteins and their annotated locations for NP_001013146.2

    Status: VALIDATED

    Source sequence(s)
    BC079285, JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q6AXW7
    UniProtKB/TrEMBL
    F1LN58
    Related
    ENSRNOP00000005516.2, ENSRNOT00000005516.6
    Conserved Domains (1) summary
    cd14573
    Location:19 → 176
    DUSP18_21; dual specificity protein phosphatases 18 and 21

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    83013850..83035168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251299.4 → XP_006251361.1  dual specificity protein phosphatase 18 isoform X1

    See identical proteins and their annotated locations for XP_006251361.1

    UniProtKB/Swiss-Prot
    Q6AXW7
    UniProtKB/TrEMBL
    F1LN58
    Conserved Domains (1) summary
    cd14573
    Location:19 → 176
    DUSP18_21; dual specificity protein phosphatases 18 and 21

  2. XM_063273205.1 → XP_063129275.1  dual specificity protein phosphatase 18 isoform X2

RNA

  1. XR_005492971.2 RNA Sequence

  2. XR_005492970.2 RNA Sequence

  3. XR_359626.5 RNA Sequence

  4. XR_005492972.2 RNA Sequence

  5. XR_005492973.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXW7.1 GenPept UniProtKB/Swiss-Prot:Q6AXW7

Gene LinkOut

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