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Antxr2 ANTXR cell adhesion molecule 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305633, updated on 2-May-2024

Summary

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Official Symbol
Antxr2provided by RGD
Official Full Name
ANTXR cell adhesion molecule 2provided by RGD
Primary source
RGD:1561294
See related
Ensembl:ENSRNOG00000000081 AllianceGenome:RGD:1561294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within reproductive process and toxin transport. Predicted to be located in external side of plasma membrane. Predicted to be integral component of membrane. Used to study anthrax disease. Human ortholog(s) of this gene implicated in fibroma and hyaline fibromatosis syndrome. Orthologous to human ANTXR2 (ANTXR cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 286.4), Heart (RPKM 233.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Antxr2 in Genome Data Viewer
Location:
14p22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (11845774..11986166)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (11541718..11682110)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (13191716..13331286)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 5 Neighboring gene PR/SET domain 8 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120096509

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ANTXR2 Knock-Out Does Not Result in the Development of Hypertension in Rats. Liu X, et al. Am J Hypertens, 2017 Feb. PMID 28077422
  2. Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. Scobie HM, et al. PLoS Pathog, 2006 Oct. PMID 17054395, Free PMC Article
  3. PCGEM1 promotes cell proliferation and migration in endometriosis by targeting miR-124-3p-mediated ANTXR2 expression. Liu Y, et al. BMC Womens Health, 2023 Mar 13. PMID 36915057, Free PMC Article
  4. Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Hanks S, et al. Am J Hum Genet, 2003 Oct. PMID 14508707, Free PMC Article
  5. Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Liu S, et al. Proc Natl Acad Sci U S A, 2009 Jul 28. PMID 19617532, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PCGEM1 promotes cell proliferation and migration in endometriosis by targeting miR-124-3p-mediated ANTXR2 expression.
    Title: PCGEM1 promotes cell proliferation and migration in endometriosis by targeting miR-124-3p-mediated ANTXR2 expression.
  2. ANTXR2 might not be associated with hypertension and thus further functional analysis is warranted to identify the causal gene at this locus.
    Title: ANTXR2 Knock-Out Does Not Result in the Development of Hypertension in Rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within collagen fibril organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within single fertilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within uterus development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anthrax toxin receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398916.1 → NP_001385845.1  anthrax toxin receptor 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    Q00IM8
    Related
    ENSRNOP00000087704.1, ENSRNOT00000119294.1
    Conserved Domains (3) summary
    cd01474
    Location:39 → 221
    vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
    pfam05586
    Location:394 → 484
    Ant_C; Anthrax receptor C-terminus region
    pfam05587
    Location:216 → 315
    Anth_Ig; Anthrax receptor extracellular domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    11845774..11986166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092655.2 → XP_038948583.1  anthrax toxin receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A6B8
    Conserved Domains (3) summary
    cd01474
    Location:39 → 221
    vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
    pfam05586
    Location:394 → 475
    Ant_C; Anthrax receptor C-terminus region
    pfam05587
    Location:216 → 315
    Anth_Ig; Anthrax receptor extracellular domain

  2. XM_063273302.1 → XP_063129372.1  anthrax toxin receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A282

RNA

  1. XR_010057380.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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Chemical Information
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