Dlg5 discs large MAGUK scaffold protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dlg5provided by RGD
Official Full Name: discs large MAGUK scaffold protein 5provided by RGD
Primary source: RGD:1308753
See related: Ensembl:ENSRNOG00000005783 AllianceGenome:RGD:1308753
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable beta-catenin binding activity and cytoskeletal protein binding activity. Predicted to be involved in several processes, including positive regulation of dendritic spine development; positive regulation of smoothened signaling pathway; and regulation of hippo signaling. Predicted to act upstream of or within several processes, including animal organ development; apical protein localization; and protein localization to adherens junction. Predicted to be located in adherens junction; ciliary basal body; and postsynaptic density. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 98.1), Lung (RPKM 46.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p16

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (125287..237334)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (75786..209735)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (120213..230312)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142459 (e-PCR)
- UniSTS:231706

RH127943 (e-PCR)
- UniSTS:211253

RH139450 (e-PCR)
- UniSTS:221536

AA986715 (e-PCR)
- UniSTS:185987

D15Rat55 (e-PCR)
- UniSTS:118407

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apical protein localization	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment or maintenance of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metanephric collecting duct development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within midbrain development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroepithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within polarized epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to adherens junction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within zonula adherens assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disks large homolog 5

Names: discs, large homolog 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001372003.1 → NP_001358932.1 disks large homolog 5

Status: VALIDATED

Source sequence(s)

AW520410, JAXUCZ010000015

UniProtKB/TrEMBL

A0A8I6GLX4, D4A3K3

Related

ENSRNOP00000096092.1, ENSRNOT00000112381.1

Conserved Domains (8) summary

cd11860
Location:1604 → 1666

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1738 → 1914

GuKc; Guanylate kinase homologues

smart00228
Location:1351 → 1433

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG1196
Location:141 → 564

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:722 → 790

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam14197
Location:545 → 585

Cep57_CLD_2; Centrosome localization domain of PPC89

pfam04822
Location:129 → 213

Takusan

pfam16610
Location:1431 → 1506

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

125287..237334

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274192.1 → XP_063130262.1 disks large homolog 5 isoform X1
XM_063274193.1 → XP_063130263.1 disks large homolog 5 isoform X2
XM_063274194.1 → XP_063130264.1 disks large homolog 5 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107247.1: Suppressed sequence

Description

NM_001107247.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: DLG5 (GeneID:9231).