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ran RAN, member RAS oncogene family [ Danio rerio (zebrafish) ]

Gene ID: 30572, updated on 19-May-2024

Summary

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Official Symbol
ranprovided by ZNC
Official Full Name
RAN, member RAS oncogene familyprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-88
See related
Ensembl:ENSDARG00000057026 AllianceGenome:ZFIN:ZDB-GENE-990415-88
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc16b04; wu:fc16b04
Summary
Predicted to enable GTP binding activity; GTPase activity; and magnesium ion binding activity. Acts upstream of or within neural retina development. Predicted to be located in cytosol and nuclear envelope. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; digestive system; eye; pronephros; and splanchnocranium. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ran in Genome Data Viewer
Location:
chromosome: 14
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (21685512..21693988)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (21388267..21396743)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S8b Neighboring gene uncharacterized LOC103908747 Neighboring gene syntaxin 3b Neighboring gene lysine (K)-specific demethylase 2Ab

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutagenesis of putative ciliary genes with the CRISPR/Cas9 system in zebrafish identifies genes required for retinal development. Hu R, et al. FASEB J, 2019 Apr. PMID 30624971
  2. Ras-Related Nuclear Protein is required for late developmental stages of retinal cells in zebrafish eyes. Lin CY, et al. Int J Dev Biol, 2015. PMID 26864484
  3. Proteomic analysis of arsenic-exposed zebrafish (Danio rerio) identifies altered expression in proteins involved in fibrosis and lipid uptake in a gender-specific manner. Carlson P, et al. Toxicol Sci, 2013 Jul. PMID 23570992
  4. Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. Can H, et al. BMC Genomics, 2020 Jul 8. PMID 32640983, Free PMC Article
  5. fgf20 is essential for initiating zebrafish fin regeneration. Whitehead GG, et al. Science, 2005 Dec 23. PMID 16373575

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in GTP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic sister chromatid segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neural retina development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
GTP-binding nuclear protein Ran
Names
GTPase Ran
ras-related nuclear protein
NP_571384.1
XP_005173151.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131309.3 → NP_571384.1  GTP-binding nuclear protein Ran

    See identical proteins and their annotated locations for NP_571384.1

    Status: VALIDATED

    Source sequence(s)
    CT955967, EH499718
    UniProtKB/Swiss-Prot
    P79735, Q7ZU75
    UniProtKB/TrEMBL
    Q6GTE7
    Related
    ENSDARP00000108629.2, ENSDART00000128717.4
    Conserved Domains (2) summary
    cd00877
    Location:10 → 175
    Ran; Ras-related nuclear proteins (Ran)/TC4 family of small GTPases
    PTZ00132
    Location:1 → 215
    PTZ00132; GTP-binding nuclear protein Ran; Provisional

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    21685512..21693988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173094.4 → XP_005173151.1  GTP-binding nuclear protein Ran isoform X1

    See identical proteins and their annotated locations for XP_005173151.1

    UniProtKB/Swiss-Prot
    P79735, Q7ZU75
    UniProtKB/TrEMBL
    Q6GTE7
    Related
    ENSDARP00000121831.1, ENSDART00000144503.3
    Conserved Domains (2) summary
    cd00877
    Location:10 → 175
    Ran; Ras-related nuclear proteins (Ran)/TC4 family of small GTPases
    PTZ00132
    Location:1 → 215
    PTZ00132; GTP-binding nuclear protein Ran; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79735.1 GenPept UniProtKB/Swiss-Prot:P79735

Gene LinkOut

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