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Samd4a sterile alpha motif domain containing 4A [ Rattus norvegicus (Norway rat) ]

Gene ID: 305826, updated on 2-May-2024

Summary

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Official Symbol
Samd4aprovided by RGD
Official Full Name
sterile alpha motif domain containing 4Aprovided by RGD
Primary source
RGD:1310361
See related
Ensembl:ENSRNOG00000010489 AllianceGenome:RGD:1310361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Samd4
Summary
Predicted to enable mRNA binding activity and translation repressor activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within positive regulation of translation. Predicted to be located in cytosol; fibrillar center; and synapse. Predicted to be active in P-body. Orthologous to human SAMD4A (sterile alpha motif domain containing 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 80.2), Heart (RPKM 53.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p14
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (22616200..22831872)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (20135994..20352131)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (23666543..23879067)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene cell growth regulator with ring finger domain 1 Neighboring gene ribosomal protein L39, pseudogene 11 Neighboring gene uncharacterized LOC102548367 Neighboring gene GTP cyclohydrolase 1 Neighboring gene uncharacterized LOC102548428

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules. Baez MV, et al. J Biol Chem, 2005 Dec 30. PMID 16221671
  2. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation repressor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation repressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein Smaug homolog 1
Names
smaug 1
sterile alpha motif domain containing 4
sterile alpha motif domain-containing protein 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399774.2 → NP_001386703.1  protein Smaug homolog 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    B5DF21
    Related
    ENSRNOP00000069646.2, ENSRNOT00000092091.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    22616200..22831872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093258.2 → XP_038949186.1  protein Smaug homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUK8, A0A0G2JVW7, A6KE35
    Related
    ENSRNOP00000069137.2
    Conserved Domains (1) summary
    cd09557
    Location:320 → 382
    SAM_Smaug; SAM domain of Smaug subfamily

  2. XM_039093259.2 → XP_038949187.1  protein Smaug homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GLX6, A6KE36
    Related
    ENSRNOP00000096104.1
    Conserved Domains (1) summary
    cd09557
    Location:238 → 294
    SAM_Smaug; SAM domain of Smaug subfamily

  3. XM_063274206.1 → XP_063130276.1  protein Smaug homolog 1 isoform X2

  4. XM_063274207.1 → XP_063130277.1  protein Smaug homolog 1 isoform X4

  5. XM_063274208.1 → XP_063130278.1  protein Smaug homolog 1 isoform X5

  6. XM_039093261.2 → XP_038949189.1  protein Smaug homolog 1 isoform X6

    UniProtKB/TrEMBL
    A6KE37

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107254.1: Suppressed sequence

    Description
    NM_001107254.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5DF21.1 GenPept UniProtKB/Swiss-Prot:B5DF21

Gene LinkOut

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