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Zdhhc20 zinc finger DHHC-type palmitoyltransferase 20 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305923, updated on 13-Apr-2024

Summary

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Official Symbol
Zdhhc20provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 20provided by RGD
Primary source
RGD:1305755
See related
Ensembl:ENSRNOG00000011024 AllianceGenome:RGD:1305755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305755
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be integral component of Golgi membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC20 (zinc finger DHHC-type palmitoyltransferase 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 174.7), Spleen (RPKM 144.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zdhhc20 in Genome Data Viewer
Location:
15p12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (36095624..36154546, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (31980057..32039006, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (38108886..38165765, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene Sin3A associated protein 18 Neighboring gene spindle and kinetochore associated complex subunit 3 Neighboring gene mitochondrial ribosomal protein L57 Neighboring gene uncharacterized LOC134482124 Neighboring gene mitochondrial calcium uptake 2 Neighboring gene uncharacterized LOC102550095 Neighboring gene fibroblast growth factor 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Fatty acyl recognition and transfer by an integral membrane S-acyltransferase. Rana MS, et al. Science, 2018 Jan 12. PMID 29326245, Free PMC Article
  2. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Ohno Y, et al. Mol Biol Cell, 2012 Dec. PMID 23034182, Free PMC Article
  3. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC156467

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC20
Names
membrane-associated DHHC24 zinc finger protein
probable palmitoyltransferase ZDHHC20
zinc finger, DHHC domain containing 20
zinc finger, DHHC-type containing 20
NP_001034425.2
XP_006252134.1
XP_008768971.1
XP_008768972.1
XP_063130338.1
XP_063130339.1
XP_063130340.1
XP_063130341.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039336.2 → NP_001034425.2  palmitoyltransferase ZDHHC20

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    Q2TGI6
    Related
    ENSRNOP00000014820.4, ENSRNOT00000014820.4
    Conserved Domains (1) summary
    cl19890
    Location:16 → 309
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    36095624..36154546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770750.4 → XP_008768972.1  palmitoyltransferase ZDHHC20 isoform X4

    Related
    ENSRNOP00000087392.1
    Conserved Domains (1) summary
    cl19890
    Location:75 → 380
    zf-DHHC; DHHC palmitoyltransferase

  2. XM_063274270.1 → XP_063130340.1  palmitoyltransferase ZDHHC20 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A7N7

  3. XM_063274268.1 → XP_063130338.1  palmitoyltransferase ZDHHC20 isoform X3

  4. XM_008770749.4 → XP_008768971.1  palmitoyltransferase ZDHHC20 isoform X2

    UniProtKB/TrEMBL
    F7FM28
    Conserved Domains (1) summary
    cl19890
    Location:75 → 380
    zf-DHHC; DHHC palmitoyltransferase

  5. XM_006252072.5 → XP_006252134.1  palmitoyltransferase ZDHHC20 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AR22, Q2TGI6
    Related
    ENSRNOP00000096907.1
    Conserved Domains (1) summary
    cl19890
    Location:75 → 380
    zf-DHHC; DHHC palmitoyltransferase

  6. XM_063274269.1 → XP_063130339.1  palmitoyltransferase ZDHHC20 isoform X5

  7. XM_063274271.1 → XP_063130341.1  palmitoyltransferase ZDHHC20 isoform X7

    UniProtKB/TrEMBL
    E9PT74
Nucleotide Protein Strain
Heading Accession and Version

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