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ANXA3 annexin A3 [ Homo sapiens (human) ]

Gene ID: 306, updated on 4-Jan-2025

Summary

Official Symbol
ANXA3provided by HGNC
Official Full Name
annexin A3provided by HGNC
Primary source
HGNC:HGNC:541
See related
Ensembl:ENSG00000138772 MIM:106490; AllianceGenome:HGNC:541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANX3
Summary
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 99.1), lung (RPKM 76.4) and 15 other tissues See more
Orthologs
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Genomic context

See ANXA3 in Genome Data Viewer
Location:
4q21.21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (78551770..78610447)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (81887335..81946029)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (79472924..79531601)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Fraser extracellular matrix complex subunit 1 Neighboring gene Sharpr-MPRA regulatory region 11576 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:79228222-79228817 Neighboring gene small nucleolar RNA, C/D box 161 Neighboring gene MICOS10 pseudogene 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:79402250-79403449 Neighboring gene Sharpr-MPRA regulatory region 1185 Neighboring gene Sharpr-MPRA regulatory region 14158 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:79455131-79456330 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:79473344-79474543 Neighboring gene uncharacterized LOC124900721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21646 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese.
EBI GWAS Catalog
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr downregulates the expression of ANXA3 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding  
enables calcium-dependent phospholipid binding  
enables calcium-dependent phospholipid binding PubMed 
enables calcium-dependent protein binding PubMed 
enables phosphatidylserine binding  
enables phospholipase A2 inhibitor activity  
Component Evidence Code Pubs
located_in axon  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in dendrite  
located_in extracellular exosome PubMed 
located_in membrane PubMed 
located_in neuronal cell body  
is_active_in nucleus  
located_in phagocytic vesicle membrane PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in specific granule PubMed 
is_active_in vesicle membrane  

General protein information

Preferred Names
annexin A3
Names
35-alpha calcimedin
Annexin III (lipocortin III)
PAP-III
annexin III (lipocortin III, 1,2-cyclic-inositol-phosphate phosphodiesterase, placental anticoagulant protein III, calcimedin 35-alpha)
annexin-3
calcimedin 35-alpha
inositol 1,2-cyclic phosphate 2-phosphohydrolase
lipocortin III
placental anticoagulant protein III
NP_005130.1
XP_047306110.1
XP_054205834.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005139.3NP_005130.1  annexin A3

    See identical proteins and their annotated locations for NP_005130.1

    Status: REVIEWED

    Source sequence(s)
    BC000871
    Consensus CDS
    CCDS3584.1
    UniProtKB/Swiss-Prot
    B2R9W6, P12429, Q6LET2
    UniProtKB/TrEMBL
    D6RA82
    Related
    ENSP00000264908.6, ENST00000264908.11
    Conserved Domains (1) summary
    pfam00191
    Location:94159
    Annexin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    78551770..78610447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047450154.1XP_047306110.1  annexin A3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    81887335..81946029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349859.1XP_054205834.1  annexin A3 isoform X1

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