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Pde12 phosphodiesterase 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306231, updated on 2-May-2024

Summary

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Official Symbol
Pde12provided by RGD
Official Full Name
phosphodiesterase 12provided by RGD
Primary source
RGD:1310975
See related
Ensembl:ENSRNOG00000059442 AllianceGenome:RGD:1310975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
2-PDE; 2'-PDE; LRRGT00074; RGD1310975
Summary
Predicted to enable 3'-5'-exoribonuclease activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to cytokine stimulus; and regulation of mitochondrial mRNA stability. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human PDE12 (phosphodiesterase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 107.6), Thymus (RPKM 84.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pde12 in Genome Data Viewer
Location:
16p16
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (1926807..1932383, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (1920062..1925638, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (2357028..2367069, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482439 Neighboring gene DENN domain containing 6A Neighboring gene ADP-ribosylation factor 4 Neighboring gene dynein, axonemal, heavy chain 12 Neighboring gene protein phosphatase 1, regulatory subunit 26, pseudogene 1 Neighboring gene ankyrin repeat and SOCS box-containing 14 Neighboring gene adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria. Rorbach J, et al. Nucleic Acids Res, 2011 Sep 1. PMID 21666256, Free PMC Article
  2. Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon. Kubota K, et al. J Biol Chem, 2004 Sep 3. PMID 15231837
  3. Characterization of human phosphodiesterase 12 and identification of a novel 2'-5' oligoadenylate nuclease - The ectonucleotide pyrophosphatase/phosphodiesterase 1. Poulsen JB, et al. Biochimie, 2012 May. PMID 22285541
  4. Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover. Poulsen JB, et al. Nucleic Acids Res, 2011 May. PMID 21245038, Free PMC Article
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to dsRNA IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to dsRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-alpha IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to type II interferon IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial mRNA stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitochondrial mRNA stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
2',5'-phosphodiesterase 12
Names
mitochondrial deadenylase
NP_001398637.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411708.1 → NP_001398637.1  2',5'-phosphodiesterase 12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    Q6AXQ5
    UniProtKB/TrEMBL
    A6KMJ7
    Related
    ENSRNOP00000073047.2, ENSRNOT00000083573.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    1926807..1932383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013998.2: Suppressed sequence

    Description
    NM_001013998.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXQ5.1 GenPept UniProtKB/Swiss-Prot:Q6AXQ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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