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Nek4 NIMA-related kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306252, updated on 6-Jun-2024

Summary

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Official Symbol
Nek4provided by RGD
Official Full Name
NIMA-related kinase 4provided by RGD
Primary source
RGD:1304995
See related
Ensembl:ENSRNOG00000017997 AllianceGenome:RGD:1304995
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable manganese ion binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of transcription, DNA-templated; protein phosphorylation; and regulation of cellular response to stress. Located in ciliary plasm; ciliary transition zone; and cytoskeleton. Orthologous to human NEK4 (NIMA related kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 47.7), Adrenal (RPKM 46.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nek4 in Genome Data Viewer
Location:
16p16
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6151292..6200280)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6144900..6185376)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7035002..7080272)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene inter-alpha trypsin inhibitor, heavy chain 3 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 1 Neighboring gene signal peptidase complex subunit 1 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene small nucleolar RNA SNORD19B Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene G protein nucleolar 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Activity and substrate specificity of the murine STK2 Serine/Threonine kinase that is structurally related to the mitotic regulator protein NIMA of Aspergillus nidulans. Hayashi K, et al. Biochem Biophys Res Commun, 1999 Oct 22. PMID 10529384
  2. Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. Nguyen CL, et al. Mol Cell Biol, 2012 Oct. PMID 22851694, Free PMC Article
  3. The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase. Coene KL, et al. Hum Mol Genet, 2011 Sep 15. PMID 21685204
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary plasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary rootlet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek4
Names
NIMA (never in mitosis gene a)-related expressed kinase 4
NIMA (never in mitosis gene a)-related kinase 4
NP_001013152.2
XP_038950371.1
XP_063131360.1
XP_063131361.1
XP_063131362.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013134.2 → NP_001013152.2  serine/threonine-protein kinase Nek4

    See identical proteins and their annotated locations for NP_001013152.2

    Status: PROVISIONAL

    Source sequence(s)
    CH474046
    UniProtKB/TrEMBL
    A0A8I6A574, A6KG16, D3ZDV9
    Related
    ENSRNOP00000024296.6, ENSRNOT00000024296.8
    Conserved Domains (2) summary
    smart00220
    Location:6 → 261
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08223
    Location:5 → 261
    STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    6151292..6200280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275290.1 → XP_063131360.1  serine/threonine-protein kinase Nek4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A574

  2. XM_039094443.2 → XP_038950371.1  serine/threonine-protein kinase Nek4 isoform X2

    Conserved Domains (1) summary
    cd08223
    Location:5 → 261
    STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

  3. XM_063275291.1 → XP_063131361.1  serine/threonine-protein kinase Nek4 isoform X3

  4. XM_063275292.1 → XP_063131362.1  serine/threonine-protein kinase Nek4 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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