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Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306375, updated on 3-Apr-2024

Summary

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Official Symbol
Csgalnact1provided by RGD
Official Full Name
chondroitin sulfate N-acetylgalactosaminyltransferase 1provided by RGD
Primary source
RGD:1307618
See related
Ensembl:ENSRNOG00000013024 AllianceGenome:RGD:1307618
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Chgn; RGD1307618
Summary
Predicted to enable hexosyltransferase activity. Predicted to be involved in chondroitin sulfate proteoglycan biosynthetic process and nucleotide-sugar metabolic process. Predicted to act upstream of or within chondroitin sulfate metabolic process; extracellular matrix organization; and skeletal system development. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Orthologous to human CSGALNACT1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 54.0), Thymus (RPKM 53.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Csgalnact1 in Genome Data Viewer
Location:
16p14
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (25761946..26097306)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (20995210..21330586)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (22704318..23075071)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482365 Neighboring gene integrator complex subunit 10 Neighboring gene ribosomal protein L10, pseudogene 7 Neighboring gene splicing factor YJU2-like Neighboring gene uncharacterized LOC120097455 Neighboring gene SH2 domain containing 4A Neighboring gene uncharacterized LOC134482490

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis. Gotoh M, et al. J Biol Chem, 2002 Oct 11. PMID 12163485
  2. Molecular cloning and expression of a human chondroitin synthase. Kitagawa H, et al. J Biol Chem, 2001 Oct 19. PMID 11514575
  3. Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism. Sato T, et al. J Biol Chem, 2011 Feb 18. PMID 21148564, Free PMC Article
  4. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Watanabe Y, et al. Biochem J, 2010 Nov 15. PMID 20812917, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidoglycan glycosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylgalactosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UDP-glucuronate metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cartilage development ISO
Inferred from Sequence Orthology
more info
  
involved_in chondroitin sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chondroitin sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chondroitin sulfate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endochondral ossification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chondroitin sulfate N-acetylgalactosaminyltransferase 1
Names
chondroitin beta1,4 N-acetylgalactosaminyltransferase
NP_001100779.1
XP_006253089.1
XP_006253090.1
XP_006253091.1
XP_008769336.1
XP_008769338.1
XP_017455585.1
XP_038950422.1
XP_038950423.1
XP_063131449.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107309.1 → NP_001100779.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_001100779.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474045
    UniProtKB/TrEMBL
    B5DEY9, F7FDK7
    Related
    ENSRNOP00000017822.4, ENSRNOT00000017822.6
    Conserved Domains (1) summary
    cl11394
    Location:68 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    25761946..26097306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275379.1 → XP_063131449.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    B5DEY9, F7FDK7

  2. XM_039094494.2 → XP_038950422.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    B5DEY9, F7FDK7
    Conserved Domains (1) summary
    cl11394
    Location:68 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  3. XM_017600096.3 → XP_017455585.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    B5DEY9, F7FDK7
    Conserved Domains (1) summary
    cl11394
    Location:68 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  4. XM_008771114.4 → XP_008769336.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_008769336.1

    UniProtKB/TrEMBL
    B5DEY9, F7FDK7
    Conserved Domains (1) summary
    cl11394
    Location:68 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  5. XM_039094495.2 → XP_038950423.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    B5DEY9, F7FDK7
    Conserved Domains (1) summary
    cl11394
    Location:68 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  6. XM_006253028.5 → XP_006253090.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006253090.1

    UniProtKB/TrEMBL
    B5DEY9, F7FDK7
    Conserved Domains (1) summary
    cl11394
    Location:68 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  7. XM_008771116.4 → XP_008769338.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_008769338.1

    UniProtKB/TrEMBL
    B5DEY9, F7FDK7
    Conserved Domains (1) summary
    cl11394
    Location:68 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  8. XM_006253029.5 → XP_006253091.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006253091.1

    UniProtKB/TrEMBL
    B5DEY9, F7FDK7
    Conserved Domains (1) summary
    cl11394
    Location:68 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  9. XM_006253027.4 → XP_006253089.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006253089.1

    UniProtKB/TrEMBL
    B5DEY9, F7FDK7
    Conserved Domains (1) summary
    cl11394
    Location:68 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Nucleotide Protein Strain
Heading Accession and Version

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