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Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306460, updated on 2-May-2024

Summary

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Symbol
Enpp6provided by RGD
Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 6provided by RGD
Primary source
RGD:1311645
See related
Ensembl:ENSRNOG00000009660 AllianceGenome:RGD:1311645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
E-NPP 6
Summary
Predicted to enable glycerophosphocholine cholinephosphodiesterase activity and glycerophosphodiester phosphodiesterase activity. Predicted to be involved in choline metabolic process and lipid metabolic process. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Orthologous to human ENPP6 (ectonucleotide pyrophosphatase/phosphodiesterase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 554.6), Adrenal (RPKM 85.6) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Enpp6 in Genome Data Viewer
Location:
16q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (51898557..52026789, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (45165883..45294126, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (48315500..48437258, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551690 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC120097575 Neighboring gene storkhead box 2 Neighboring gene uncharacterized LOC103693959 Neighboring gene uncharacterized LOC102551895 Neighboring gene uncharacterized LOC120097410 Neighboring gene prothymosin alpha like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase. Morita J, et al. Sci Rep, 2016 Feb 18. PMID 26888014, Free PMC Article
  2. Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. Sakagami H, et al. J Biol Chem, 2005 Jun 17. PMID 15788404
  3. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycerophosphocholine cholinephosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerophosphocholine cholinephosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycerophosphocholine cholinephosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycerophosphodiester phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerophosphodiester phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoric diester hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in choline metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within choline metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in choline metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in choline metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycerophosphocholine cholinephosphodiesterase ENPP6
Names
E-NPP6
GPC-Cpde
NPP-6
choline-specific glycerophosphodiester phosphodiesterase
ectonucleotide pyrophosphatase/phosphodiesterase family member 6
ectonucleotide pyrophosphatase/phosphodiesterase family member 6-like
NP_001402007.1
XP_008769481.1
XP_038950452.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415078.1 → NP_001402007.1  glycerophosphocholine cholinephosphodiesterase ENPP6 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    B0BND0
    Related
    ENSRNOP00000013005.5, ENSRNOT00000013005.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    51898557..52026789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771259.4 → XP_008769481.1  glycerophosphocholine cholinephosphodiesterase ENPP6 isoform X1

    UniProtKB/TrEMBL
    A6JPM3, D3ZRI1
    Related
    ENSRNOP00000056157.2
    Conserved Domains (2) summary
    pfam01663
    Location:26 → 357
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:24 → 374
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  2. XM_039094524.2 → XP_038950452.1  glycerophosphocholine cholinephosphodiesterase ENPP6 isoform X2

    UniProtKB/TrEMBL
    A6JPM3, D3ZRI1
    Conserved Domains (1) summary
    pfam01663
    Location:26 → 332
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107311.1: Suppressed sequence

    Description
    NM_001107311.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0BND0.1 GenPept UniProtKB/Swiss-Prot:B0BND0

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